Capture and release of circulating tumor cells stimulated by pH and NIR irradiation of magnetic Fe3O4@ZIF-8 nanoparticles

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2023-04-01 DOI:10.1016/j.colsurfb.2023.113206

Jidong Wang , Yating Zhang , Min Dong , Zhaopeng Liu , Binbin Guo , Haipeng Zhang , Liming Gao

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引用次数: 1

Abstract

Detecting and analyzing circulating tumor cells(CTCs) is significant for early diagnosis, management, and personalized treatment of tumors. Herein, a smart magnetic aptamer modified Fe₃O₄@ZIF-8 core/shell structured nanoparticle (NPs) was successfully constructed using for capture and simultaneous pH- and NIR-irradiation responsive release of CTCs. Taking MCF-7 as model CTCs, it could be captured ca. 60 % in low-concentration artificial blood by aptamer (SYL3C) on the surface of Fe₃O₄@ZIF-8 NPs. After magnetic separation, the ZIF-8 shell in aptamer-modified Fe₃O₄@ZIF-8 NPs carrying captured CTCs would disintegrate within 20 min under the synergistic effect of an acidic environment (pH=6.0) and NIR irradiation leading to the release of CTCs with high cell viability, which was benefited for the subsequent culture and analysis. This magnetic and core/shell structured device integrated high-efficiency capture, quick isolation and perfect release into one system, which showed great potentials for the detection of CTCs in the clinic.

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磁性Fe3O4@ZIF-8纳米颗粒pH和近红外照射刺激循环肿瘤细胞的捕获和释放

检测和分析循环肿瘤细胞(CTCs)对肿瘤的早期诊断、管理和个性化治疗具有重要意义。本文成功构建了一种智能磁性适配体修饰的Fe3O4@ZIF-8核/壳结构纳米颗粒(NPs)，用于捕获和同时pH和nir辐照响应释放ctc。以MCF-7为模型ctc, Fe3O4@ZIF-8 NPs表面的适体(SYL3C)在低浓度人工血液中可捕获约60%的ctc。磁性分离后，在酸性环境(pH=6.0)和近红外辐射的协同作用下，携带捕获的CTCs的核酸适体修饰Fe3O4@ZIF-8 NPs中的ZIF-8外壳在20 min内分解，释放出具有较高细胞活力的CTCs，有利于后续的培养和分析。该磁性和核/壳结构装置集高效捕获、快速分离和完美释放于一体，在临床CTCs检测中具有很大的应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.