Complement 3 Receptor Expression in Individuals with Type 2 Diabetes.

Q3 Medicine

Recent patents on anti-infective drug discovery Pub Date : 2016-01-01 DOI:10.2174/1574891X11666160608121617

Judy Ly, Devin Morris, Minette Lagman, Christopher Ng, Shelby Anderson, John Daliva, Naji Muwanas, Igal Tarash, Cesar Ochoa, Airani Sathananthan, Vishwanath Venketaraman

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引用次数: 1

Abstract

Background: According to the World Health Organization, as of 2014 9% of the world's adult population is affected by diabetes. Uncontrolled diabetes is a pro-inflammatory process that increases generation of reactive oxygen species (ROS).

Methods: The production of ROS leads to a chronic increase in oxidative stress which results in an increased susceptibility to infections. Individuals with type 2 diabetes mellitus (T2DM) are highly susceptible to Mycobacterium tuberculosis (M. tb) infection. Previous research has demonstrated that glutathione (GSH) plays an important role in the control of M. tb infection. Recent studies have demonstrated that phagocytosis of M.tb is diminished in patients with T2DM. Phagocytosis in macrophages is thought to be mediated in part by complement protein 3b (C3b)-complement protein receptor 3b (C3R) interactions. Since C3b production is not diminished in patients with T2DM we propose that C3R production is reduced and is the cause for impaired macrophage phagocytosis as well as IL-12 and IFN-γ signaling.

Conclusion: This study utilizes a quantitative PCR (qPCR), demonstrating decreased transcription of C3R mRNA in patients with T2DM as compared to non-diabetics.

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补体3受体在2型糖尿病患者中的表达

背景:根据世界卫生组织的数据，截至2014年，全球9%的成年人患有糖尿病。不受控制的糖尿病是一个促炎过程，增加活性氧(ROS)的产生。方法:ROS的产生导致氧化应激的慢性增加，从而导致对感染的易感性增加。2型糖尿病(T2DM)患者对结核分枝杆菌(M. tb)感染非常敏感。以往的研究表明谷胱甘肽(GSH)在结核分枝杆菌感染的控制中起着重要作用。最近的研究表明，结核分枝杆菌的吞噬能力在T2DM患者中减弱。巨噬细胞的吞噬作用被认为部分是由补体蛋白3b (C3b)-补体蛋白受体3b (C3R)相互作用介导的。由于T2DM患者的C3b生成并未减少，我们认为C3R生成减少是巨噬细胞吞噬功能受损以及IL-12和IFN-γ信号传导受损的原因。结论:本研究利用定量PCR (qPCR)，证明T2DM患者的C3R mRNA转录比非糖尿病患者减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Recent patents on anti-infective drug discovery Medicine-Pharmacology (medical)

CiteScore

2.40

自引率

0.00%

发文量

期刊介绍： Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.