Effects of Laminaria japonica polysaccharides on exercise endurance and oxidative stress in forced swimming mouse model.

IF 1.9 3区生物学 Q2 BIOLOGY

Journal of Biological Research-Thessaloniki Pub Date : 2016-04-26 eCollection Date: 2016-12-01 DOI:10.1186/s40709-016-0049-4

Feiwei Yan, Haitao Hao

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引用次数: 22

Abstract

Background: Polysaccharides are the major active ingredients responsible for the bioactivities of Laminaria japonica. However, the effects of L. japonica polysaccharides (LJP) on exercise endurance and oxidative stress have never been investigated. Therefore, this study was conducted to investigate the effects of LJP on exercise endurance and oxidative stress in a forced swimming mouse model. The animals were divided into four groups, namely the control (C), LJP-75, LJP-150, and LJP-300 groups, which received physiological saline and 75, 150, and 300 mg kg(-1) LJP, respectively, by gavage once a day for 28 days. This was followed by a forced swimming test and measurements of various biochemical parameters.

Results: LJP increased swimming time to exhaustion, the liver and muscle glycogen content, and levels of superoxide dismutase, glutathione peroxidase, and catalase in the serum, liver, and muscle, which were accompanied by corresponding decreases in the malondialdehyde (MDA) content of the same tissues. Furthermore, decreases in blood lactic acid and serum myeloperoxidase (MPO) levels were observed.

Conclusion: LJP enhanced exercise endurance and protected mice against exhaustive exercise-induced oxidative stress.

Abstract Image

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海带多糖对强迫游泳小鼠运动耐力和氧化应激的影响。

背景:多糖是海带生物活性的主要活性成分。然而，枸杞多糖(LJP)对运动耐力和氧化应激的影响尚未见报道。因此，本研究旨在探讨LJP对强迫游泳小鼠运动耐力和氧化应激的影响。将实验动物分为对照组(C)、LJP-75组、LJP-150组和LJP-300组，分别给予生理盐水和75、150、300 mg kg(-1) LJP，每天灌胃1次，连用28 d。随后进行了强制游泳测试和各种生化参数的测量。结果:LJP增加了游泳至衰竭时间，增加了血清、肝脏和肌肉中糖原含量，增加了血清、肝脏和肌肉中超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶水平，并相应降低了同一组织中丙二醛(MDA)含量。此外，观察到血乳酸和血清髓过氧化物酶(MPO)水平降低。结论:枸杞多糖可增强小鼠运动耐力，保护小鼠抗运动性氧化应激。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biological Research-Thessaloniki 生物-生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Biological Research-Thessaloniki is a peer-reviewed, open access, international journal that publishes articles providing novel insights into the major fields of biology. Topics covered in Journal of Biological Research-Thessaloniki include, but are not limited to: molecular biology, cytology, genetics, evolutionary biology, morphology, development and differentiation, taxonomy, bioinformatics, physiology, marine biology, behaviour, ecology and conservation.