Brain Magnetic Stimulation in Animal Models: A Valuable Lesson for Clinical Applications.

IF 3 4区 医学 Q3 NEUROSCIENCES
Begona M Escribano, Abel Santamaría, María E de Lima, Francisco J Medina-Fernández, Shahid Bashir, Isaac Túnez
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引用次数: 5

Abstract

Transcranial magnetic stimulation (TMS) is more than a mere tool for clinical non-invasive approaches to stimulate and synchronize the neuronal activity in the brain. Electromagnetic stimulation through TMS has recently emerged as a therapeutic alternative for the treatment of different neurological disorders. Among the many properties recently discovered for TMS, its action as an accounting factor for neuroplasticity and neurogenesis is among its most promising features. Translational studies in animal models offer various advantages and also bridge this knowledge gap due to their direct assessment of the brain stimulation impact at the neural level. These profiles have been obtained through the study of animal models, which, in turn, have served for the establishment of the action mechanisms of this method. In this review, we revise and discuss evidence collected on the promising properties of TMS after visiting the different animal models developed so far, and provide a practical perspective of its possible application for clinical purposes.

脑磁刺激动物模型:临床应用的宝贵经验。
经颅磁刺激(TMS)不仅仅是一种临床非侵入性方法来刺激和同步大脑神经元活动的工具。通过经颅磁刺激的电磁刺激最近成为治疗不同神经系统疾病的一种治疗选择。在最近发现的经颅磁刺激的许多特性中,其作为神经可塑性和神经发生的一个考虑因素的作用是其最有前途的特征之一。动物模型的转化研究提供了各种优势,也弥补了这一知识差距,因为它们直接评估了脑刺激在神经水平上的影响。这些轮廓是通过动物模型的研究获得的,而动物模型的研究反过来又为该方法的作用机制的建立服务。在本文中,我们通过对迄今为止开发的不同动物模型的回顾,对所收集到的有关经颅磁刺激具有前景的证据进行了修订和讨论,并对其可能的临床应用前景进行了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.10
自引率
3.30%
发文量
158
审稿时长
6-12 weeks
期刊介绍: Aims & Scope CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes. CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.
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