Biomedical therapy using synthetic WKYMVm hexapeptide.

IF 1.6 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Organogenesis Pub Date : 2016-04-02 Epub Date: 2016-04-14 DOI:10.1080/15476278.2016.1172155
Young Hwan Choi, Il Ho Jang, Soon Chul Heo, Jae Ho Kim, Nathaniel S Hwang
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引用次数: 9

Abstract

WKYMVm hexapeptide has been identified as a strong FPR2 agonist through a library screening of synthetic peptides. The FPR2 has been reported to play a crucial role in inflammation and angiogenic responses via stimulation of chemotaxis, migration, cell proliferation, wound healing and vessel growth. Recently, the therapeutic effects of WKYMVm have been reported in various disease models. In cutaneous wound model in diabetic mice, WKYMVm facilitated wound healing processes by stimulating the formation of capillary and arteriole and re-epithelialization. In coronary artery stenosis model, WKYMVm coating on stent promoted re-endothelialization and lowered restenosis rate. In hindlimb ischemia mouse model, intramuscular injection of WKYMVm promoted homing of exogenously transplanted endothelial colony-forming cells and neovascularization, resulting in salvaging hindlimb. Furthermore, a single injection of WKYMVm encapsulated in poly (lactide-co-glycolide) microspheres was demonstrated to be as efficient as multiple injections of WKYMVm in restoring blood flow in hindlimb ischemia model. These observations may open up promising biomedical applications of WKYMVm for tissue repairs and regenerations.

Abstract Image

Abstract Image

利用合成WKYMVm六肽进行生物医学治疗。
WKYMVm六肽已通过合成肽库筛选确定为强FPR2激动剂。据报道,FPR2通过刺激趋化性、迁移、细胞增殖、伤口愈合和血管生长,在炎症和血管生成反应中发挥关键作用。最近,WKYMVm在各种疾病模型中的治疗作用已被报道。在糖尿病小鼠皮肤创面模型中,WKYMVm通过刺激毛细血管和小动脉的形成和再上皮化促进创面愈合。在冠状动脉狭窄模型中,支架涂层WKYMVm促进再内皮化,降低再狭窄率。在小鼠后肢缺血模型中,肌内注射WKYMVm可促进外源性移植内皮集落形成细胞的归巢和新生血管的形成,从而挽救后肢。此外,在后肢缺血模型中,单次注射包封在聚乳酸-羟基乙酸酯微球中的WKYMVm与多次注射WKYMVm在恢复血流方面同样有效。这些观察结果可能为WKYMVm在组织修复和再生方面的生物医学应用开辟了前景。
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来源期刊
Organogenesis
Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY
CiteScore
4.10
自引率
4.30%
发文量
6
审稿时长
>12 weeks
期刊介绍: Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.
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