Impact of Opioid and Nonopioid Drugs on Postsurgical Pain Management in the Rat.

Q2 Medicine
Pain Research and Treatment Pub Date : 2016-01-01 Epub Date: 2016-03-16 DOI:10.1155/2016/8364762
Natalie M Wilson, Matthew S Ripsch, Fletcher A White
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引用次数: 6

Abstract

Aim. Nonsteroidal anti-inflammatory drugs or opioids are commonly used to control surgical pain following veterinary and clinical procedures. This study evaluated the efficacy of postoperative ketorolac or buprenorphine following abdominal surgery. Main Methods. Mean arterial pressure (MAP), heart rate, animal activity, corticosterone levels, and a nociceptive sensitivity assay were used to evaluate 18 adult male Sprague-Dawley rats which underwent aortic artery occlusion for implantation of a radiotelemetry device. The animals were treated postoperatively with intraperitoneal injections of vehicle, ketorolac (10 mg/kg), or buprenorphine (0.06 mg/kg) every 8 hours for 3 days. Key Findings. There were no consistent significant changes in any of the telemetry parameters after treatment with ketorolac compared with no saline treatment with the exception of increased MAP in the buprenorphine group during the first 48 hours when compared with other treatment groups. There was a sustained increase in fecal corticosterone levels from baseline on days 2-7 with buprenorphine compared with vehicle- or ketorolac-treated animals. All treatment conditions displayed reduced paw withdrawal thresholds (PWTs) from day 1 to day 21 following surgery. Compared with the vehicle treatment group, buprenorphine-treated animals exhibited significantly lower PWT levels from day 4 to 14 days. Significance. Given the prolonged increase in fecal corticosterone levels and pronounced changes in tactile hyperalgesia behavior in rodents subjected to buprenorphine treatment, these data suggest that ketorolac may be superior to buprenorphine for the treatment of postprocedure pain behavior in rodents.

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阿片类药物和非阿片类药物对大鼠术后疼痛管理的影响。
的目标。非甾体类抗炎药或阿片类药物通常用于控制兽医和临床手术后的手术疼痛。本研究评估腹部手术后使用酮咯酸或丁丙诺啡的疗效。主要方法。采用平均动脉压(MAP)、心率、动物活动、皮质酮水平和伤害敏感性试验对18只成年雄性Sprague-Dawley大鼠进行评估,这些大鼠接受了主动脉闭塞术以植入无线电遥测装置。术后每8小时腹腔注射一次载药、酮咯酸(10 mg/kg)或丁丙诺啡(0.06 mg/kg),连续3天。关键的发现。除丁丙诺啡组与其他治疗组相比在前48小时内MAP增加外,酮酸治疗后与无生理盐水治疗相比,任何遥测参数均无一致的显著变化。丁丙诺啡与对照药或酮咯酸治疗的动物相比,在第2-7天,粪便皮质酮水平从基线持续增加。从手术后第1天到第21天,所有治疗条件下的患者都显示出爪断阈值(PWTs)的降低。与载药组相比,丁丙诺啡处理的动物在第4天至第14天的PWT水平显著降低。的意义。考虑到丁丙诺啡治疗后啮齿动物粪便皮质酮水平的长期升高和触觉痛觉过敏行为的显著变化,这些数据表明酮咯酸可能优于丁丙诺啡治疗啮齿动物手术后疼痛行为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pain Research and Treatment
Pain Research and Treatment Medicine-Anesthesiology and Pain Medicine
CiteScore
3.60
自引率
0.00%
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0
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