Trans-inactivation: Repression in a wrong place.

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Fly Pub Date : 2017-04-03 Epub Date: 2016-08-19 DOI:10.1080/19336934.2016.1225634

Aleksei S Shatskikh, Yuriy A Abramov, Sergey A Lavrov

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引用次数: 6

Abstract

Trans-inactivation is the repression of genes on a normal chromosome under the influence of a rearranged homologous chromosome demonstrating the position effect variegation (PEV). This phenomenon was studied in detail on the example of brown^Dominant allele causing the repression of wild-type brown gene on the opposite chromosome. We have investigated another trans-inactivation-inducing chromosome rearrangement, In(2)A4 inversion. In both cases, brown^Dominant and In(2)A4, the repression seems to be the result of dragging of the euchromatic region of the normal chromosome into the heterochromatic environment. It was found that cis-inactivation (classical PEV) and trans-inactivation show different patterns of distribution along the chromosome and respond differently to PEV modifying genes. It appears that the causative mechanism of trans-inactivation is de novo heterochromatin assembly on euchromatic sequences dragged into the heterochromatic nuclear compartment. Trans-inactivation turns out to be the result of a combination of heterochromatin-induced position effect and the somatic interphase chromosome pairing that is widespread in Diptera.

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反式失活:抑制在错误的地方。

反式失活是在同源染色体重排的影响下正常染色体上基因的抑制，表现为位置效应变异(PEV)。以引起野生型棕色基因在对侧染色体上被抑制的棕色显性等位基因为例，详细研究了这一现象。我们研究了另一种反式失活诱导的染色体重排，In(2)A4倒置。在brownDominant和In(2)A4两种情况下，抑制似乎是正常染色体的正染色质区域被拖到异染色质环境中的结果。研究发现，顺式失活(典型的PEV)和反式失活在染色体上的分布模式不同，对PEV修饰基因的反应也不同。反式失活的致病机制似乎是在常染色质序列上重新组装异染色质，并将其拖入异染色质核室。反式失活是异染色质诱导的位置效应和双翅目中普遍存在的体细胞间期染色体配对共同作用的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fly 生物-生化与分子生物学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Fly is the first international peer-reviewed journal to focus on Drosophila research. Fly covers a broad range of biological sub-disciplines, ranging from developmental biology and organogenesis to sensory neurobiology, circadian rhythm and learning and memory, to sex determination, evolutionary biology and speciation. We strive to become the “to go” resource for every researcher working with Drosophila by providing a forum where the specific interests of the Drosophila community can be discussed. With the advance of molecular technologies that enable researchers to manipulate genes and their functions in many other organisms, Fly is now also publishing papers that use other insect model systems used to investigate important biological questions. Fly offers a variety of papers, including Original Research Articles, Methods and Technical Advances, Brief Communications, Reviews and Meeting Reports. In addition, Fly also features two unconventional types of contributions, Counterpoints and Extra View articles. Counterpoints are opinion pieces that critically discuss controversial papers questioning current paradigms, whether justified or not. Extra View articles, which generally are solicited by Fly editors, provide authors of important forthcoming papers published elsewhere an opportunity to expand on their original findings and discuss the broader impact of their discovery. Extra View authors are strongly encouraged to complement their published observations with additional data not included in the original paper or acquired subsequently.