{"title":"Mixed Epithelial and Stromal Tumor of the Kidney with Sarcomatous Transformation Metastatic to the Lung. A Case Report.","authors":"Yasemin Ozluk, Sule Ozturk Sari, Nalan Turan Guzel, Pinar Firat, Fatih Akbulut, Isin Kilicaslan","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Malignant transformation of mixed epithelial and stromal tumor (MEST) of the kidney is a very rare entity. We report an unusual case with a review of the literature.</p><p><strong>Case: </strong>A 25-year-old woman underwent surgery for an 8-cm biphasic renal tumor, which was diagnosed as MEST of the kidney. High cellularity, mitoses, and nuclear atypia seen in the stromal component were compatible with a sarcomatous transformation in MEST. The patient also had pulmonary metastatic nodules that were resected 2 months after the nephrectomy. Metastatic pulmonary tumors were morphologically identical to the sarcomatous component of the renal tumor and showed pulmonary epithelial hyperplasia with a phyllodes-like pattern.</p><p><strong>Conclusion: </strong>Although MEST of the kidney is known as a benign tumor, malignant transformation, mostly sarcomatous type, should be considered in the diagnosis.</p>","PeriodicalId":55517,"journal":{"name":"Analytical and Quantitative Cytopathology and Histopathology","volume":"37 3","pages":"199-205"},"PeriodicalIF":0.1000,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical and Quantitative Cytopathology and Histopathology","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
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Abstract
Background: Malignant transformation of mixed epithelial and stromal tumor (MEST) of the kidney is a very rare entity. We report an unusual case with a review of the literature.
Case: A 25-year-old woman underwent surgery for an 8-cm biphasic renal tumor, which was diagnosed as MEST of the kidney. High cellularity, mitoses, and nuclear atypia seen in the stromal component were compatible with a sarcomatous transformation in MEST. The patient also had pulmonary metastatic nodules that were resected 2 months after the nephrectomy. Metastatic pulmonary tumors were morphologically identical to the sarcomatous component of the renal tumor and showed pulmonary epithelial hyperplasia with a phyllodes-like pattern.
Conclusion: Although MEST of the kidney is known as a benign tumor, malignant transformation, mostly sarcomatous type, should be considered in the diagnosis.
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