Identification of multiple genetic loci in the mouse controlling immobility time in the tail suspension and forced swimming tests.

IF 0.4 4区农林科学 Q4 VETERINARY SCIENCES

Japanese Journal of Veterinary Research Pub Date : 2015-05-01

Ahmed F Abou-Elnaga, Daisuke Torigoe, Mohamed M Fouda, Ragab A Darwish, Usama A Abou-Ismail, Masami Morimatsu, Takashi Agui

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引用次数: 0

Abstract

Depression is one of the most famous psychiatric disorders in humans in all over the countries and considered a complex neurobehavioral trait and difficult to identify causal genes. Tail suspension test (TST) and forced swimming test (FST) are widely used for assessing depression-like behavior and antidepressant activity in mice. A variety of antidepressant agents are known to reduce immobility time in both TST and FST. To identify genetic determinants of immobility duration in both tests, we analyzed 101 F2 mice from an intercross between C57BL/6 and DBA/2 strains. Quantitative trait locus (QTL) mapping using 106 microsatellite markers revealed three loci (two significant and one suggestive) and five suggestive loci controlling immobility time in the TST and FST, respectively. Results of QTL analysis suggest a broad description of the genetic architecture underlying depression, providing underpinnings for identifying novel molecular targets for antidepressants to clear the complex genetic mechanisms of depressive disorders.

本刊更多论文

小鼠悬尾和强制游泳试验中控制不动时间的多个基因位点的鉴定。

抑郁症是世界上最著名的人类精神疾病之一，被认为是一种复杂的神经行为特征，难以确定病因基因。尾悬试验(TST)和强迫游泳试验(FST)被广泛用于评估小鼠抑郁样行为和抗抑郁活性。已知多种抗抑郁药物可减少TST和FST的静止时间。为了确定两种实验中固定时间的遗传决定因素，我们分析了101只来自C57BL/6和DBA/2菌株杂交的F2小鼠。利用106个微卫星标记进行定量性状位点(QTL)定位，分别发现3个位点(2个显著位点和1个提示位点)和5个提示位点控制静止时间。QTL分析的结果为抑郁症的遗传结构提供了广泛的描述，为确定抗抑郁药物的新分子靶点以清除抑郁症复杂的遗传机制提供了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Journal of Veterinary Research 农林科学-兽医学

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： The Japanese Journal of Veterinary Research (JJVR) quarterly publishes peer-reviewed articles on all aspects of veterinary science. JJVR was originally published as a “University Journal” of veterinary science at Hokkaido University from more than 60 years ago. Currently, JJVR, is Japan’s leading scientific veterinary journal, and provides valuable information for the development of veterinary science by welcoming contributions from researchers worldwide. JJVR offers online submission for Regular Papers, Short Communications, and Review Articles that are unpublished and not being considered for publication elsewhere. Research areas include: Anatomy, Physiology, Biochemistry, Pharmacology, Microbiology, Infectious diseases, Parasitology, Laboratory Animal Science and Medicine, Internal Medicine, Surgery, Pathology, Theriogenology, Molecular Medicine, Public Health, Radiation Biology, Toxicology, Wildlife Biology and Medicine, Veterinary Hygiene, The other fields related to veterinary science.