Nanomaterial translocation--the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs--a review.

IF 5.7 2区 医学 Q1 TOXICOLOGY
Critical Reviews in Toxicology Pub Date : 2015-01-01 Epub Date: 2015-07-03 DOI:10.3109/10408444.2015.1058747
Ali Kermanizadeh, Dominique Balharry, Håkan Wallin, Steffen Loft, Peter Møller
{"title":"Nanomaterial translocation--the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs--a review.","authors":"Ali Kermanizadeh,&nbsp;Dominique Balharry,&nbsp;Håkan Wallin,&nbsp;Steffen Loft,&nbsp;Peter Møller","doi":"10.3109/10408444.2015.1058747","DOIUrl":null,"url":null,"abstract":"<p><p>Engineered nanomaterials (NMs) offer great technological advantages but their risks to human health are still not fully understood. An increasing body of evidence suggests that some NMs are capable of distributing from the site of exposure to a number of secondary organs. The research into the toxicity posed by the NMs in these secondary organs is expanding due to the realisation that some materials may reach and accumulate in these target sites. The translocation to secondary organs includes, but is not limited to, the hepatic, central nervous, cardiovascular and renal systems. Current data indicates that pulmonary exposure is associated with low (inhalation route-0.00001-1% of total applied dose-24 h) translocation of virtually insoluble NMs such as iridium, carbon black, gold and polystyrene, while slightly higher translocation has been observed for NMs with either slow (e.g., silver, cerium dioxide and quantum dots) or fast (e.g., zinc oxide) solubility. The translocation of NMs following intratracheal, intranasal and pharyngeal aspiration is higher (up to 10% of administered dose), however the relevance of these routes for risk assessment is questionable. Uptake of the materials from the gastrointestinal tract seems to follow the same pattern as inhalation translocation, whereas the dermal uptake of NMs is generally reported to be low. The toxicological effects in secondary organs include oxidative stress, inflammation, cytotoxicity and dysfunction of cellular and physiological processes. For toxicological and risk evaluation, further information on the toxicokinetics and persistence of NMs is crucial. The overall aim of this review is to outline the data currently available in the literature on the biokinetics, accumulation, toxicity and eventual fate of NMs in order to assess the potential risks posed by NMs to secondary organs.</p>","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":"45 10","pages":"837-72"},"PeriodicalIF":5.7000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10408444.2015.1058747","citationCount":"126","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical Reviews in Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3109/10408444.2015.1058747","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2015/7/3 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 126

Abstract

Engineered nanomaterials (NMs) offer great technological advantages but their risks to human health are still not fully understood. An increasing body of evidence suggests that some NMs are capable of distributing from the site of exposure to a number of secondary organs. The research into the toxicity posed by the NMs in these secondary organs is expanding due to the realisation that some materials may reach and accumulate in these target sites. The translocation to secondary organs includes, but is not limited to, the hepatic, central nervous, cardiovascular and renal systems. Current data indicates that pulmonary exposure is associated with low (inhalation route-0.00001-1% of total applied dose-24 h) translocation of virtually insoluble NMs such as iridium, carbon black, gold and polystyrene, while slightly higher translocation has been observed for NMs with either slow (e.g., silver, cerium dioxide and quantum dots) or fast (e.g., zinc oxide) solubility. The translocation of NMs following intratracheal, intranasal and pharyngeal aspiration is higher (up to 10% of administered dose), however the relevance of these routes for risk assessment is questionable. Uptake of the materials from the gastrointestinal tract seems to follow the same pattern as inhalation translocation, whereas the dermal uptake of NMs is generally reported to be low. The toxicological effects in secondary organs include oxidative stress, inflammation, cytotoxicity and dysfunction of cellular and physiological processes. For toxicological and risk evaluation, further information on the toxicokinetics and persistence of NMs is crucial. The overall aim of this review is to outline the data currently available in the literature on the biokinetics, accumulation, toxicity and eventual fate of NMs in order to assess the potential risks posed by NMs to secondary organs.

纳米材料易位——生物动力学、组织蓄积、毒性和材料在次生器官中的命运——综述。
工程纳米材料(NMs)具有巨大的技术优势,但其对人类健康的风险仍未完全了解。越来越多的证据表明,一些NMs能够从暴露部位分布到许多次要器官。由于认识到某些物质可能到达并积聚在这些靶部位,对NMs对这些次生器官的毒性的研究正在扩大。向次要器官的转移包括但不限于肝脏、中枢神经、心血管和肾脏系统。目前的数据表明,肺暴露与几乎不溶性NMs(如铱、炭黑、金和聚苯乙烯)的低易位(吸入途径-总剂量的0.00001-1% -24小时)有关,而已观察到的NMs的易位稍高,其溶解度或慢(如银、二氧化铈和量子点)或快(如氧化锌)。气管内、鼻内和咽内滴入后NMs的易位较高(高达给药剂量的10%),但这些途径与风险评估的相关性值得怀疑。从胃肠道吸收这些物质似乎遵循与吸入转运相同的模式,而据报道,NMs的皮肤吸收通常很低。次生器官的毒理学效应包括氧化应激、炎症、细胞毒性以及细胞和生理过程的功能障碍。对于毒理学和风险评估,进一步了解NMs的毒性动力学和持久性是至关重要的。本综述的总体目的是概述目前文献中关于NMs的生物动力学,积累,毒性和最终命运的数据,以评估NMs对次要器官构成的潜在风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
9.50
自引率
1.70%
发文量
29
期刊介绍: Critical Reviews in Toxicology provides up-to-date, objective analyses of topics related to the mechanisms of action, responses, and assessment of health risks due to toxicant exposure. The journal publishes critical, comprehensive reviews of research findings in toxicology and the application of toxicological information in assessing human health hazards and risks. Toxicants of concern include commodity and specialty chemicals such as formaldehyde, acrylonitrile, and pesticides; pharmaceutical agents of all types; consumer products such as macronutrients and food additives; environmental agents such as ambient ozone; and occupational exposures such as asbestos and benzene.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信