Effect of Pistacia atlantica Fruit and Leaf Extracts on Hydatid Cyst Protoscolices.

Q3 Medicine

Recent patents on anti-infective drug discovery Pub Date : 2016-01-01 DOI:10.2174/1574891x10666151029113334

Mohammad Zibaei, Reza Rostamipour, Hassan Nayebzadeh

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引用次数: 14

Abstract

Background: Treatment of human hydatidosis is mainly surgical, with chemical treatment being reserved as a coadjuvant treatment. Use of effective protoscolicidal agents during surgery of hydatid disease is essential to reduce the recurrence rate.

Objective: The aim of this study was to investigate the scolicidal effects of Pistacia atlantica leaf and fruit hydroalcoholic extracts on protoscolices of hydatid cyst.

Method: Echinococcus granulosus protoscolices were obtained from 50 sheep infected with hydatid cysts. Various concentrations of plant hydroalcoholic extracts were used in different exposure times for viability assay of protoscolices.

Results: The scolicidal effects of the hydroalcoholic extracts of the leaf, fresh and dried fruits were significant compared to the control groups (P < 0.05). Among the Pistacia atlantica extracts tested, 0.1% (mg/ml) concentrations of fresh fruit extract (99.09 ± 1.27) and leaf extract (89.25 ± 18.42) had strong scolicidal effects in 360 min, of exposure times and the mortality rate decreased with the lower concentration.

Conclusion: Information from the current study has the strong scolicidal effect of fresh fruit hydroalcoholic extract of Pistacia atlantica on protoscoleces, which may be used as a scolicidal agent during the surgery techniques.

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大西洋木果叶提取物对包虫病原侧凸的影响。

背景:人类包虫病的治疗主要是手术治疗，化学治疗保留作为辅助治疗。在包虫病手术中使用有效的原脊柱灭菌剂对降低复发率是必要的。目的:研究木黄连叶和木黄连果水醇提取物对棘球蚴原棘突的杀虫作用。方法:从50只羊包虫病感染中提取原棘球蚴。采用不同浓度的植物水醇提取物和不同的暴露时间对原脊柱进行了活力测定。结果:与对照组相比，枸杞叶、鲜果和干果水醇提取物的杀侧骨作用显著(P < 0.05)。其中，0.1% (mg/ml)浓度的鲜果提取物(99.09±1.27)和叶提取物(89.25±18.42)在360 min的暴露时间内具有较强的杀侧作用，且死亡率随浓度的降低而降低。结论:本研究结果表明，新鲜水果水酒精提取物对原头节有较强的杀侧骨作用，可作为手术技术中的杀侧骨剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Recent patents on anti-infective drug discovery Medicine-Pharmacology (medical)

CiteScore

2.40

自引率

0.00%

发文量

期刊介绍： Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.