PET Imaging of Steroid Hormone Receptor Expression.

IF 2.2 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS
Louis Allott, Graham Smith, Eric O Aboagye, Laurence Carroll
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引用次数: 0

Abstract

Steroid hormone receptor (SHR) expression and changes in SHR expression compared to basal levels, whether upregulated, downregulated, or mutated, form a distinguishing feature of some breast, ovarian, and prostate cancers. These receptors act to induce tumor proliferation. In the imaging context, total expression together with modulation of expression can yield predictive and prognostic information. Currently, biopsy for histologic assessment of SHR expression is routine for breast and prostate cancer; however, the technique is not well suited to the heterogeneous tumor environment and can lead to incorrect receptor expression assignment, which precludes effective treatment. The development of positron emission tomography (PET) radioligands to image receptor expression may overcome the difficulties associated with tumor heterogeneity and facilitate the assessment of metastatic disease.

类固醇激素受体表达的 PET 成像。
类固醇激素受体(SHR)的表达以及与基础水平相比SHR表达的变化,无论是上调、下调还是突变,都是一些乳腺癌、卵巢癌和前列腺癌的显著特征。这些受体可诱导肿瘤增殖。在成像方面,总表达和表达调节可产生预测和预后信息。目前,对乳腺癌和前列腺癌进行活检以对 SHR 表达进行组织学评估已成为常规做法;然而,该技术并不适合异质性肿瘤环境,可能导致受体表达分配错误,从而无法进行有效治疗。开发正电子发射断层扫描(PET)放射配体来成像受体表达,可以克服肿瘤异质性带来的困难,并促进转移性疾病的评估。
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来源期刊
Molecular Imaging
Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology
自引率
3.60%
发文量
21
期刊介绍: Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.
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