Differential Diagnosis for Multiple Sclerosis-related Optic Neuritis.

眼科学报 Pub Date : 2015-03-01

Yan Zhang, Xiaolei Liang, Shihui Wei, Hongyang Li

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引用次数: 0

Abstract

Purpose: To analyze clinical features and main causes of multiple sclerosis-related optic neuritis (MS-ON), providing evidence for the differential diagnosis of MS-ON.

Methods: Clinical data were collected from 527 patients, 123 males and 404 females, diagnosed with MS-ON between June 2008 and June 2013. Visual acuity, optometry, visual field, slit-lamp microscopy, indirect ophthalmoscopy (20D), optical coherence tomography (OCT) and magnetic resonance imaging (MRI) were performed. Venous blood was sampled for detection of autoimmune antibodies and Aquaporin (AQP- 4).

Results: Fifty nine cases were diagnosed with neuromyelitis optica-related optic neuritis (NMO-ON), 27 Sjogren's syndrome-related optic neuropathy, 22 tumors, 21 anterior ischemic optic neuropathy, 15 radiation-induced optic neuropathy, 14 optic neuropathy-related infection, 17 genetic eye diseases and 10 open angle glaucoma. Among 168 MS-ON patients undergoing optic nerve MRI,90 cases (53.57%) had a lesion < 15 mm in size, 15-30 mm in 76 (45.24%) and > 30 mm in two (1.19%).

Conclusion: MS-ON is more commonly misdiagnosed with NMO-ON and Sjogren's syndrome, when compared to optic neuropathy, tumors and ischemic optic neuropathy.

本刊更多论文

多发性硬化相关视神经炎的鉴别诊断。

目的:分析多发性硬化相关性视神经炎(MS-ON)的临床特点及主要病因，为MS-ON的鉴别诊断提供依据。方法:收集2008年6月至2013年6月诊断为MS-ON的527例患者的临床资料，其中男性123例，女性404例。检查视力、验光、视野、裂隙灯显微镜、间接眼镜检查(20D)、光学相干断层扫描(OCT)和磁共振成像(MRI)。结果:诊断为视神经脊髓炎(NMO-ON) 59例，干燥综合征相关视神经病变27例，肿瘤22例，前路缺血性视神经病变21例，放射线性视神经病变15例，视神经病变相关感染14例，遗传性眼病17例，开角型青光眼10例。168例视神经MRI MS-ON患者中，病变大小< 15 mm者90例(53.57%)，15-30 mm者76例(45.24%)，> 30 mm者2例(1.19%)。结论:与视神经病变、肿瘤和缺血性视神经病变相比，MS-ON更易误诊为NMO-ON和干燥综合征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

眼科学报

自引率

0.00%

发文量

1312

期刊介绍： Eye science was founded in 1985. It is a national medical journal supervised by the Ministry of Education of the People's Republic of China, sponsored by Sun Yat-sen University, and hosted by Sun Yat-sen University Zhongshan Eye Center (in October 2020, it was changed from a quarterly to a monthly, with the publication number: ISSN: 1000-4432; CN: 44-1119/R). It is edited by Ge Jian, former dean of Sun Yat-sen University Zhongshan Eye Center, Liu Yizhi, director and dean of Sun Yat-sen University Zhongshan Eye Center, and Lin Haotian, deputy director of Sun Yat-sen University Zhongshan Eye Center, as executive editor. It mainly reports on new developments and trends in the field of ophthalmology at home and abroad, focusing on basic research in ophthalmology, clinical experience, and theoretical knowledge and technical operations related to epidemiology. It has been included in important databases at home and abroad, such as Chemical Abstract (CA), China Journal Full-text Database (CNKI), China Core Journals (Selection) Database (Wanfang), and Chinese Science and Technology Journal Database (VIP).