Stem cell aging in adult progeria

IF 4 Q2 CELL & TISSUE ENGINEERING

Cell Regeneration Pub Date : 2015-01-01 DOI:10.1186/s13619-015-0021-z

Hoi-Hung Cheung , Duanqing Pei , Wai-Yee Chan

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引用次数: 7

Abstract

Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatric diseases. Advanced age-related decline in physiological functions, such as neurodegeneration, development of cardiovascular disease, endocrine and metabolic dysfunction, and neoplastic transformation, has become the focus in aging research. Natural aging is not regarded as a programmed process. However, accelerated aging due to inherited genetic defects in patients of progeria is programmed and resembles many aspects of natural aging. Among several premature aging syndromes, Werner syndrome (WS) and Hutchinson–Gilford progeria syndrome (HGPS) are two broadly investigated diseases. In this review, we discuss how stem cell aging in WS helps us understand the biology of aging. We also discuss briefly how the altered epigenetic landscape in aged cells can be reversed to a “juvenile” state. Lastly, we explore the potential application of the latest genomic editing technique for stem cell-based therapy and regenerative medicine in the context of aging.

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成人早衰症的干细胞老化

衰老被认为是一个不可逆转的生物过程，也是一系列老年病的主要危险因素。衰老相关的生理功能衰退，如神经退行性变、心血管疾病的发展、内分泌和代谢功能障碍、肿瘤转化等，已成为衰老研究的重点。自然衰老不被认为是一个程序化的过程。然而，早衰症患者由于遗传缺陷导致的加速衰老是程序化的，与自然衰老的许多方面相似。在几种早衰综合征中，Werner综合征(WS)和Hutchinson-Gilford progeria syndrome (HGPS)是两种被广泛研究的疾病。在这篇综述中，我们讨论了WS中的干细胞衰老如何帮助我们理解衰老的生物学。我们还简要讨论了如何改变的表观遗传景观在衰老细胞可以逆转到一个“少年”状态。最后，我们探讨了最新的基因组编辑技术在干细胞治疗和再生医学中的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine