A Novel Endoscopic Cerenkov Luminescence Imaging System for Intraoperative Surgical Navigation.

IF 2.2 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS
Molecular Imaging Pub Date : 2015-01-01
Tianming Song, Xia Liu, Yawei Qu, Haixiao Liu, Chengpeng Bao, Chengcai Leng, Zhenhua Hu, Kun Wang, Jie Tian
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引用次数: 0

Abstract

Cerenkov luminescence imaging is an emerging optical technique for imaging the distribution of radiopharmaceuticals in vivo. However, because of the light scattering effect, it cannot obtain optical information from deep internal organs. To overcome this challenge, we established a novel endoscopic Cerenkov luminescence imaging system that used a clinically approved laparoscope and an electron-multiplying charge-coupled device camera. We assessed the performance of the system through a series of in vitro and in vivo experiments. The results demonstrated superior superficial imaging resolution (0.1 mm), a large field of view (500 mm2 with 10 mm imaging distance), and superb imaging sensitivity (imaging 1 μCi) of our system. It captured the weak Cerenkov signal from internal organs successfully and was applied to intraoperative surgical navigation of tumor resection. It offered objective information of the tumor location and tumor residual during the surgical operation. This technique holds great potential for clinical translation.

一种用于手术导航的新型内窥镜切伦科夫发光成像系统。
切伦科夫发光成像是一种用于放射性药物在体内分布成像的新兴光学技术。然而,由于光散射效应,它无法获得深层器官的光学信息。为了克服这一挑战,我们建立了一种新型的内窥镜切伦科夫发光成像系统,该系统使用临床认可的腹腔镜和电子倍增电荷耦合器件相机。我们通过一系列体外和体内实验来评估该系统的性能。结果表明,该系统具有良好的表面成像分辨率(0.1 mm),大视场(500 mm2,成像距离为10 mm)和出色的成像灵敏度(成像1 μCi)。该系统成功捕获了来自内脏器官的弱切伦科夫信号,并应用于肿瘤切除术中导航。它提供了手术过程中肿瘤位置和残留情况的客观信息。该技术具有很大的临床应用潜力。
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来源期刊
Molecular Imaging
Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology
自引率
3.60%
发文量
21
期刊介绍: Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.
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