Wnt signaling induces epithelial differentiation during cutaneous wound healing.

IF 1.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Organogenesis Pub Date : 2015-01-01 DOI:10.1080/15476278.2015.1086052

Khosrow S Houschyar, Arash Momeni, Malcolm N Pyles, Zeshaan N Maan, Alexander J Whittam, Frank Siemers

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引用次数: 71

Abstract

Cutaneous wound repair in adult mammals typically does not regenerate original dermal architecture. Skin that has undergone repair following injury is not identical to intact uninjured skin. This disparity may be caused by differences in the mechanisms that regulate postnatal cutaneous wound repair compared to embryonic skin development and thus we seek a deeper understanding of the role that Wnt signaling plays in the mechanisms of skin repair in both fetal and adult wounds. The influence of secreted Wnt signaling proteins in tissue homeostasis has galvanized efforts to identify small molecules that target Wnt-mediated cellular responses. Wnt signaling is activated by wounding and participates in every subsequent stage of the healing process from the control of inflammation and programmed cell death, to the mobilization of stem cell reservoirs within the wound site. Endogenous Wnt signaling augmentation represents an attractive option to aid in the restoration of cutaneous wounds, as the complex mechanisms of the Wnt pathway have been increasingly investigated over the years. In this review, we summarize recent data elucidating the roles that Wnt signaling plays in cutaneous wound healing process.

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Wnt信号在皮肤伤口愈合过程中诱导上皮分化。

成年哺乳动物的皮肤伤口修复通常不会再生原有的皮肤结构。受伤后进行修复的皮肤与未受伤的完整皮肤是不一样的。这种差异可能是由于与胚胎皮肤发育相比，出生后皮肤伤口修复的调节机制存在差异，因此我们寻求更深入地了解Wnt信号在胎儿和成人伤口皮肤修复机制中所起的作用。分泌的Wnt信号蛋白对组织稳态的影响促使人们努力识别靶向Wnt介导的细胞反应的小分子。Wnt信号被损伤激活，并参与愈合过程的每个后续阶段，从控制炎症和程序性细胞死亡，到伤口部位干细胞库的动员。内源性Wnt信号增强是帮助皮肤伤口修复的一个有吸引力的选择，因为Wnt通路的复杂机制近年来已经得到越来越多的研究。在这篇综述中，我们总结了最近阐明Wnt信号在皮肤伤口愈合过程中所起作用的数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY

CiteScore

4.10

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.