Influenza A Virus Infection, Innate Immunity, and Childhood.

IF 24.7 1区 医学 Q1 PEDIATRICS
Bria M Coates, Kelly L Staricha, Kristin M Wiese, Karen M Ridge
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引用次数: 54

Abstract

Infection with influenza A virus is responsible for considerable morbidity and mortality in children worldwide. While it is apparent that adequate activation of the innate immune system is essential for pathogen clearance and host survival, an excessive inflammatory response to infection is detrimental to the young host. A review of the literature indicates that innate immune responses change throughout childhood. Whether these changes are genetically programmed or triggered by environmental cues is unknown. The objectives of this review are to summarize the role of innate immunity in influenza A virus infection in the young child and to highlight possible differences between children and adults that may make children more susceptible to severe influenza A infection. A better understanding of age-related differences in innate immune signaling will be essential to improve care for this high-risk population.

Abstract Image

Abstract Image

甲型流感病毒感染、先天免疫和儿童。
甲型流感病毒感染是全世界儿童发病率和死亡率较高的原因。虽然先天免疫系统的充分激活对病原体清除和宿主生存至关重要,但对感染的过度炎症反应对年轻宿主是有害的。文献综述表明,先天免疫反应在整个儿童时期发生变化。这些变化是由基因决定的,还是由环境因素引发的,目前尚不清楚。本综述的目的是总结先天免疫在幼儿甲型流感病毒感染中的作用,并强调儿童和成人之间可能存在的差异,这些差异可能使儿童更容易感染严重的甲型流感。更好地了解先天免疫信号中与年龄相关的差异对于改善对这一高危人群的护理至关重要。
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来源期刊
JAMA Pediatrics
JAMA Pediatrics PEDIATRICS-
CiteScore
31.60
自引率
1.90%
发文量
357
期刊介绍: JAMA Pediatrics, the oldest continuously published pediatric journal in the US since 1911, is an international peer-reviewed publication and a part of the JAMA Network. Published weekly online and in 12 issues annually, it garners over 8.4 million article views and downloads yearly. All research articles become freely accessible online after 12 months without any author fees, and through the WHO's HINARI program, the online version is accessible to institutions in developing countries. With a focus on advancing the health of infants, children, and adolescents, JAMA Pediatrics serves as a platform for discussing crucial issues and policies in child and adolescent health care. Leveraging the latest technology, it ensures timely access to information for its readers worldwide.
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