[MORPHOFUNCTIONAL PARAMETERS OF BLOOD CELLS OF THE RAT WITH 1,2-DIMETHYLHYDRAZINE-INDUCED COLON CARCINOGENESIS].

TSitologiia i genetika Pub Date : 2015-05-01

I V Byelinska, O V Lynchak, T V Rybalchenko, S V Yablonska, O M Bahurynska, V K Rybalchenko

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Abstract

Morphofunctional parameters of blood cells of the rats with dimethylhydrazine induced colon carcinogenesis have been investigated. The reduction of Mean corpuscular hemoglobin (MCH) and Mean corpuscular hemoglobin concentration (MCHC) whereas increasing of reticulocytes number and indirect bilirubin after 20 weeks of experiment of dimethylhydrazine (DMH)-induced colon carcinogenesis indicate the hemolysis of red blood cells due to the DMH influence during tumors development. The moderate increasing of monocytes and platelets number, as well as increment of eosinophilic granulocytes number have been observed. 26 weeks of experiment (after 6 weeks discontinuation of DMH) leads to reduction of hemoglobin and erythrocytes number, a moderate increase of monocytes number and increment of platelets number in rats blood. The anemia with thrombocytosis accompany cancer in humans and the model of DMH-induced colon cancer is appropriate not only for studies of carcinogenesis and searching of new antineoplastic drugs, but also for the development of the correctional approaches of cancer-associated changes in the hematopoietic system.

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1,2-二甲基肼致结肠癌大鼠血细胞形态功能参数。

本文研究了二甲肼诱导大鼠结肠癌的血细胞形态功能参数。二甲基肼(DMH)诱导结肠癌实验20周后，平均红细胞血红蛋白(MCH)和平均红细胞血红蛋白浓度(MCHC)降低，网状红细胞数量和间接胆红素增加，表明肿瘤发展过程中DMH的影响导致红细胞溶血。单核细胞和血小板数量适度增加，嗜酸性粒细胞数量增加。实验第26周(停用DMH 6周后)，大鼠血液中血红蛋白和红细胞数量减少，单核细胞数量适度增加，血小板数量增加。人类伴有血小板增多的贫血伴癌和dmh诱导结肠癌模型不仅适用于研究癌变和寻找新的抗肿瘤药物，而且适用于开发造血系统癌症相关变化的纠正方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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TSitologiia i genetika

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