Expression and significance of CDX2, FXR, and TGR5 in esophageal cancer.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-09-15 eCollection Date: 2022-01-01

Hongying Zhang, Xiaodong Qu, Na Wang, Lifeng Zhang, Ting Yuan, Miao Shi, Nina Sun, Donghong Yuan, Hanbing Ning, Mengyun Zhao, Yongxi Wang, Zhen Ni, Chuan Han, Yongquan Shi

{"title":"Expression and significance of CDX2, FXR, and TGR5 in esophageal cancer.","authors":"Hongying Zhang, Xiaodong Qu, Na Wang, Lifeng Zhang, Ting Yuan, Miao Shi, Nina Sun, Donghong Yuan, Hanbing Ning, Mengyun Zhao, Yongxi Wang, Zhen Ni, Chuan Han, Yongquan Shi","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>This study explored the expression and significance of three critical morphogenesis genes in normal esophagus, reflux esophagitis (RE), Barrett's esophagus (BE), esophageal adenocarcinoma (EA), and esophageal squamous cell carcinoma (ESCC). Esophageal tissue samples and tissue microarrays were used. CDX2, FXR, and TGR5 protein expression were measured by immunohistochemistry in normal esophageal, RE, BE, EA, and ESCC tissues. All 3 proteins had markedly changed expression during the progression of EA. The expressions of CDX2 and FXR were positively correlated in EA. In addition, TGR5 expression was positively correlated with CDX2 in RE and BE. The expressions of CDX2 and FXR were also positively correlated in ESCC. Although CDX2, FXR, and TGR5 were upregulated in ESCC, these factors might not be markers for the prognosis of ESCC. These results suggested that CDX2, FXR, and TGR5 might play different roles in EA and ESCC. They may represent novel therapeutic targets for patients with these cancers.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547995/pdf/ijcep0015-0354.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

This study explored the expression and significance of three critical morphogenesis genes in normal esophagus, reflux esophagitis (RE), Barrett's esophagus (BE), esophageal adenocarcinoma (EA), and esophageal squamous cell carcinoma (ESCC). Esophageal tissue samples and tissue microarrays were used. CDX2, FXR, and TGR5 protein expression were measured by immunohistochemistry in normal esophageal, RE, BE, EA, and ESCC tissues. All 3 proteins had markedly changed expression during the progression of EA. The expressions of CDX2 and FXR were positively correlated in EA. In addition, TGR5 expression was positively correlated with CDX2 in RE and BE. The expressions of CDX2 and FXR were also positively correlated in ESCC. Although CDX2, FXR, and TGR5 were upregulated in ESCC, these factors might not be markers for the prognosis of ESCC. These results suggested that CDX2, FXR, and TGR5 might play different roles in EA and ESCC. They may represent novel therapeutic targets for patients with these cancers.

本刊更多论文

CDX2、FXR、TGR5在食管癌中的表达及意义

本研究探讨3个关键形态发生基因在正常食管、反流性食管炎(RE)、Barrett食管(BE)、食管腺癌(EA)和食管鳞状细胞癌(ESCC)中的表达及其意义。使用食管组织样本和组织微阵列。免疫组化法检测正常食管、RE、BE、EA和ESCC组织中CDX2、FXR和TGR5蛋白的表达。在EA的进展过程中，3种蛋白的表达均发生了显著变化，其中CDX2和FXR在EA中的表达呈正相关，TGR5在RE和BE中的表达与CDX2呈正相关。CDX2和FXR在ESCC中的表达也呈正相关。虽然CDX2、FXR和TGR5在ESCC中表达上调，但这些因子可能不是ESCC预后的标志。提示CDX2、FXR和TGR5可能在EA和ESCC中发挥不同的作用。它们可能代表了这些癌症患者新的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.