The UHRF protein family in epigenetics, development, and carcinogenesis.

IF 4.4 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2022-01-01 DOI:10.2183/pjab.98.021

Motoko Unoki, Hiroyuki Sasaki

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引用次数: 5

Abstract

The UHRF protein family consists of multidomain regulatory proteins that sense modification status of DNA and/or proteins and catalyze the ubiquitylation of target proteins. Through their functional domains, they interact with other molecules and serve as a hub for regulatory networks of several important biological processes, including maintenance of DNA methylation and DNA damage repair. The UHRF family is conserved in vertebrates and plants but is missing from fungi and many nonvertebrate animals. Mammals commonly have UHRF1 and UHRF2, but, despite their high structural similarity, the two paralogues appear to have distinct functions. Furthermore, UHRF1 and UHRF2 show different expression patterns and different outcomes in gene knockout experiments. In this review, we summarize the current knowledge on the molecular function of the UHRF family in various biological pathways and discuss their roles in epigenetics, development, gametogenesis, and carcinogenesis, with a focus on the mammalian UHRF proteins.

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UHRF蛋白家族在表观遗传学、发育和癌变中的作用。

UHRF蛋白家族由多结构域调控蛋白组成，它们感知DNA和/或蛋白质的修饰状态并催化靶蛋白的泛素化。通过它们的功能域，它们与其他分子相互作用，并作为几个重要生物过程的调控网络的枢纽，包括维持DNA甲基化和DNA损伤修复。UHRF家族在脊椎动物和植物中保守，但在真菌和许多非脊椎动物中缺失。哺乳动物通常有UHRF1和UHRF2，但是，尽管它们的结构高度相似，这两个旁系似乎有不同的功能。此外，UHRF1和UHRF2在基因敲除实验中表现出不同的表达模式和不同的结果。本文综述了UHRF家族在各种生物学途径中的分子功能，并讨论了其在表观遗传学、发育、配子体发生和致癌中的作用，重点介绍了哺乳动物UHRF蛋白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences 生物-综合性期刊

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Proceedings of the Japan Academy Ser. B (PJA-B) is a scientific publication of the Japan Academy with a 90-year history, and covers all branches of natural sciences, except for mathematics, which is covered by the PJA-A. It is published ten times a year and is distributed widely throughout the world and can be read and obtained free of charge through the world wide web.