Quantitative bone SPECT/CT for evaluating treatment response in patient with sternoclavicular arthritis.

IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Acta radiologica open Pub Date : 2022-10-04 eCollection Date: 2022-10-01 DOI:10.1177/20584601221128409

Hisashi Komoto, Kazuhiro Kitajima, Naoto Azuma, Masao Tamura, Hiroyuki Yokoyama, Tatsuya Tsuchitani, Koichiro Yamakado

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Abstract

We report here a case of sternoclavicular arthritis due to SAPHO syndrome in a 60-year-old female in which quantitative values determined using bone SPECT/CT were useful to evaluate response. After celecoxib and alendronate sodium hydrate therapy, the chief complaints were well relieved and post-treatment Tc-99m HMDP bone SPECT/CT examination showed decreased uptake. The maximum standardized uptake value (SUV), peak SUV, mean SUV, metabolic bone volume, and total bone uptake of the untreated lesion were 18, 16, 10, 17 mL, and 180, respectively, which were decreased to 8, 7, 5, 15 mL, and 75, respectively, after the treatment. In comparison with pre-treatment situation, those parameters were decreased by -56%, -56%, -50%, -12%, and -58%, respectively, following celecoxib and alendronate sodium hydrate therapy, likely reflecting treatment response. Quantitative bone SPECT/CT may be useful to evaluate joint inflammatory activity and treatment response in a patient with osteoartritis.

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定量骨SPECT/CT评价胸锁骨关节炎患者的治疗效果。

我们在此报告一例60岁女性因SAPHO综合征而患胸锁关节炎的病例，其中使用骨SPECT/CT确定的定量值有助于评估反应。在塞来昔布和阿仑膦酸钠治疗后，主诉得到了很好的缓解，治疗后Tc-99m HMDP骨SPECT/CT检查显示摄取减少。未治疗病变的最大标准化摄取值(SUV)、峰值SUV、平均SUV、代谢骨体积和总骨摄取分别为18、16、10、17 mL和180，治疗后分别降至8、7、5、15 mL和75。与治疗前相比，塞来昔布和阿仑膦酸钠治疗后，这些参数分别下降了-56%、-56%、-50%、-12%和-58%，可能反映了治疗效果。定量骨SPECT/CT可能有助于评估骨关节炎患者的关节炎症活动和治疗反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acta radiologica open

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12 weeks