Expression of TRIM44 and its correlation with TLR4 in laryngeal squamous cell carcinoma.

Cellular and molecular biology (Noisy-le-Grand, France) Pub Date : 2022-06-30 DOI:10.14715/cmb/2022.68.6.9

Jing Bai, Xiangyi Liu, Shurong Zhang, Shoutao Dang, Yong Zhang, Guojun Zhang

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引用次数: 1

Abstract

Some members of the tripartite motif-containing protein family have been reported as important regulators of carcinogenesis. In the present study, it was investigated whether tripartite motif-containing protein 44 (TRIM44) acts as a pro-oncogene through their over-expression in laryngeal squamous cell carcinoma. Its results showed that TRIM44 was up-regulated in tumor tissues and cell lines of laryngeal squamous cell carcinoma. In vitro, knockdown of TRIM44 significantly inhibited cell growth of laryngeal squamous cell carcinoma. Furthermore, TRIM44 knockdown inhibited tumor growth in nude mice in vivo, further suggesting the oncogenic activity of TRIM44 in laryngeal squamous cell carcinoma. Also, TRIM44 positively correlated with TLR4 at the mRNA and protein levels, and Si-RNA-NF-κB restrained laryngeal squamous cell carcinoma from proliferating. All indicated that TRIM44 might play a key role in tumor invasion through their over-expression and inhibition of TRIM44 is an effective strategy for the treatment of laryngeal squamous cell carcinoma.

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TRIM44在喉部鳞状细胞癌中的表达及其与TLR4的相关性

据报道，含有三方基序蛋白家族的一些成员是致癌的重要调节因子。本研究探讨了TRIM44在喉部鳞状细胞癌中是否通过过表达发挥癌前基因的作用。结果表明，TRIM44在喉鳞癌肿瘤组织和细胞系中表达上调。在体外，敲低TRIM44可显著抑制喉鳞癌细胞的生长。此外，TRIM44敲低可抑制裸鼠体内肿瘤生长，进一步提示TRIM44在喉鳞癌中的致癌活性。TRIM44在mRNA和蛋白水平上与TLR4呈正相关，Si-RNA-NF-κB抑制喉鳞癌的增殖。提示TRIM44可能通过过表达在肿瘤侵袭中发挥关键作用，抑制TRIM44是治疗喉鳞癌的有效策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cellular and molecular biology (Noisy-le-Grand, France)

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