Impact of Body Mass Index on 5-Year Survival Rates in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.

IF 2.3 Q3 NUTRITION & DIETETICS

Nutrition and Metabolic Insights Pub Date : 2022-10-07 eCollection Date: 2022-01-01 DOI:10.1177/11786388221128362

Takashi Aoyama, Akifumi Notsu, Koki Ichimaru, Kinuko Hayashi, Masanori Tsuji, Kanako Yoshitsugu, Masafumi Fukaya, Terukazu Enami, Takashi Ikeda

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Abstract

Background: Cancer survival is associated with body mass index (BMI). However, the impact of patients' baseline characteristics on allogeneic hematopoietic stem cell transplantation (allo-HSCT) outcomes remains unclear. This study aimed to examine the baseline clinical factors associated with 5-year survival rates in patients undergoing allo-HSCT.

Material and methods: This was a retrospective exploratory observational study. Patients (n = 113, 52 women; average age: 55 years) who underwent allo-HSCT at the Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center, between January 2008 and March 2015, were included in the present study.

Results: Patients with low BMI (<18.5 kg/m²) had significantly lower 5-year survival rates than those with normal (18.5-24.9 kg/m²) and high (⩾25.0 kg/m²) BMI. The 5-year survival rate was poorer for patients with sarcopenia (41.5%) than that for those without sarcopenia prior to allo-HSCT (P = .05). The 5-year survival rate was poorer for patients with geriatric nutritional risk index (GNRI < 98) (34.5%) than that for those without GNRI prior to allo-HSCT (P < .01).

Conclusions: Low BMI before allo-HCST pre-treatment was a predictor of 5-year survival rates in this study. Patients undergoing allo-HSCT may require nutritional interventions during pre-treatment to reduce the risk of sarcopenia and GNRI (<98), which affects their survival rates.

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体重指数对同种异体造血干细胞移植患者5年生存率的影响。

背景:癌症生存与身体质量指数(BMI)相关。然而，患者的基线特征对同种异体造血干细胞移植(alloo - hsct)结果的影响尚不清楚。本研究旨在探讨与接受同种异体造血干细胞移植患者5年生存率相关的基线临床因素。材料和方法:本研究为回顾性探索性观察性研究。患者(n = 113, 52名女性;2008年1月至2015年3月期间在静冈癌症中心血液学和干细胞移植部接受同种异体造血干细胞移植的患者(平均年龄:55岁)纳入本研究。结果:低BMI(2)的患者的5年生存率明显低于正常(18.5-24.9 kg/m2)和高(小于或等于25.0 kg/m2) BMI的患者。同种异体造血干细胞移植前，肌肉减少症患者的5年生存率(41.5%)低于无肌肉减少症患者(P = 0.05)。老年营养风险指数(GNRI P)患者的5年生存率较差。结论:在本研究中，同种异体hcst治疗前的低BMI是5年生存率的预测因子。接受同种异体造血干细胞移植的患者可能需要在治疗前进行营养干预，以降低肌肉减少症和GNRI的风险(

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition and Metabolic Insights NUTRITION & DIETETICS-

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focusing on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels. This journal welcomes new manuscripts for peer review on the following topics: Nutrition, including the biochemistry of metabolism, Exercise and associated physical processes, Clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes, Research at the molecular, cellular and organismal levels, Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.