The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-09-01 DOI:10.4149/gpb_2022033

Paulína Pidíková, Barbora Chovancová, Boris Mravec, Iveta Herichová

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Abstract

Study was focused on regulatory interactions between the circadian system and the renin-angiotensin system in control of microRNA (miRNA) biosynthesis. Responsiveness of the miRNA biosynthetic pathway, selected pre-miRNAs and clock genes to angiotensin II (AngII) infusion was analysed in the suprachiasmatic nuclei (SCN), liver, kidney and heart during a 24-h cycle. per2 exerted a rhythmic expression profile in all analysed tissues. clock expression showed a rhythmic pattern in the peripheral tissues with tissue-specific response to AngII. dgcr8 expression showed a tissue-specific rhythm only in peripheral tissues, which diminished in the heart and kidney after AngII delivery. Expression of pre-miR-30c was rhythmic in all studied peripheral tissues, pre-miR-34a expression exerted significant rhythm only in the liver. AngII delivery increased expression of pre-miR-30c and pre-miR-34a in the kidney. To conclude, peripheral oscillators are more likely to exhibit rhythmic miRNA biosynthesis responsive to AngII in a tissue-specific manner compared to SCN.

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大鼠视交叉上核和外周组织dgcr8、drosha和dicer的24小时表达模式及血管紧张素II对其的调节。

研究的重点是昼夜节律系统和肾素-血管紧张素系统在控制microRNA (miRNA)生物合成中的调节相互作用。在24小时周期内，我们分析了视交叉上核(SCN)、肝脏、肾脏和心脏中miRNA生物合成途径、选定的前miRNA和时钟基因对血管紧张素II (AngII)输注的反应性。Per2在所有分析的组织中表现出节律性表达谱。时钟的表达在周围组织中表现出节律性模式，对AngII有组织特异性反应。dgcr8表达仅在外周组织中表现出组织特异性节律，在AngII分娩后心脏和肾脏中表达减少。pre-miR-30c的表达在所有研究的外周组织中都具有节律性，pre-miR-34a的表达仅在肝脏中具有显著的节律性。AngII递送增加了pre-miR-30c和pre-miR-34a在肾脏中的表达。综上所述，与SCN相比，外周振荡细胞更有可能以组织特异性的方式表现出对AngII有反应的节律性miRNA生物合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.