Effect of low and high dose of favipiravir on ovarian and reproductive function in female rats: Biochemical and histopathological evaluation.

IF 1.3 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

General physiology and biophysics Pub Date : 2022-09-01 DOI:10.4149/gpb_2022036

Serdar Balcı, Çağdaş Çöllüoğlu, Bülent Yavuzer, Seval Bulut, Fikret Altındağ, Nergis Akbaş, Halis Süleyman

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引用次数: 1

Abstract

Favipiravir is a drug which shows antiviral activity by inhibiting RNA-dependent RNA polymerase. Favipiravir causes severe adverse effects at high doses. The aim of this study was to investigate the effects of low and high dose favipiravir on ovarian and reproductive function in female rats. The rats were divided into three groups: HG group (healthy rats), FAV-100 group (rats administered 100 mg/kg favipiravir), and FAV-400 group (rats administered 400 mg/kg favipiravir) with 12 rats in each group. Favipiravir was administered orally twice daily for 1 week. Six rats from each group were euthanized and their ovaries were removed. Oxidative and antioxidant parameters were measured in ovarian tissues and examined histopathologically. The remaining animals were kept to breed. Animals receiving favipiravir had increased oxidant content, decreased antioxidant activity, decreased histopathological damage, infertility, and gestational delay. Favipiravir treatment should be used with caution, especially in women of reproductive age.

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低剂量和高剂量法匹拉韦对雌性大鼠卵巢和生殖功能的影响:生化和组织病理学评价。

Favipiravir是一种通过抑制RNA依赖性RNA聚合酶显示抗病毒活性的药物。高剂量的法匹拉韦会引起严重的副作用。本研究旨在探讨低剂量和高剂量法匹拉韦对雌性大鼠卵巢和生殖功能的影响。将大鼠分为3组:HG组(健康大鼠)、FAV-100组(大鼠给予100 mg/kg法匹拉韦)和FAV-400组(大鼠给予400 mg/kg法匹拉韦)，每组12只。Favipiravir每日口服2次，连用1周。每组处死6只大鼠，切除卵巢。测定卵巢组织的氧化和抗氧化参数，并进行组织病理学检查。剩下的动物被留下来繁殖。服用favipiravir的动物氧化剂含量增加，抗氧化活性降低，组织病理学损伤减少，不孕症和妊娠延迟。Favipiravir治疗应谨慎使用，尤其是育龄妇女。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

General physiology and biophysics 生物-生化与分子生物学

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： General Physiology and Biophysics is devoted to the publication of original research papers concerned with general physiology, biophysics and biochemistry at the cellular and molecular level and is published quarterly by the Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences.