Small Molecules Pushing Erythroid/Megakaryocyte Cell Specification Boundaries.

IF 1.2 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Cellular reprogramming Pub Date : 2022-10-01 DOI:10.1089/cell.2022.0107

Johan Flygare

引用次数: 0

Abstract

A combination of a MEK/ERK-signaling inhibitor and three chromatin-remodeling molecules enhances generation of platelet-producing megakaryocytes in vitro, possibly through direct reprogramming.

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小分子推动红/巨核细胞规格界限。

MEK/ erk信号抑制剂和三种染色质重塑分子的组合可能通过直接重编程增强体外血小板生成巨核细胞的产生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular reprogramming CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY

CiteScore

2.50

自引率

6.20%

发文量

审稿时长

3 months

期刊介绍： Cellular Reprogramming is the premier journal dedicated to providing new insights on the etiology, development, and potential treatment of various diseases through reprogramming cellular mechanisms. The Journal delivers information on cutting-edge techniques and the latest high-quality research and discoveries that are transforming biomedical research. Cellular Reprogramming coverage includes: Somatic cell nuclear transfer and reprogramming in early embryos Embryonic stem cells Nuclear transfer stem cells (stem cells derived from nuclear transfer embryos) Generation of induced pluripotent stem (iPS) cells and/or potential for cell-based therapies Epigenetics Adult stem cells and pluripotency.