Investigation of cytokine polymorphisms on viral infections after renal transplantation exhibit association between IFN-γ +874 A > T and CMV manifestations

IF 2.3 4区医学 Q3 GENETICS & HEREDITY

International Journal of Immunogenetics Pub Date : 2022-10-03 DOI:10.1111/iji.12601

Stéphanie Gomes Santos de Almeida, Fabiana Batalha Knakcfuss, Lívia Maria Assis, Regina Celia Gonçalves de Sousa, Tereza Azevedo Matuck, Deise de Boni Monteiro de Carvalho, Ricardo Luiz Dantas Machado, Maria Angelica Arpon Marandino Guimarães, Rafael Brandão Varella

引用次数: 0

Abstract

We investigated the effects of TNF-α, IFN-γ, IL-10 polymorphisms on viral infections (CMV, BKPyV, HHV-6, EBV) after renal transplantation. IFN-γ+874 A > T (lower IFN production) was associated with CMV disease (p = .039) in patients under mycophenolate-based therapy and graft failure (p = .025). This study underscores the role of IFN-γ+874 SNP in CMV infection.

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肾移植后病毒感染的细胞因子多态性研究显示IFN-γ +874 A > T与巨细胞病毒表现相关

我们研究了TNF-α、IFN-γ、IL-10多态性对肾移植后病毒(CMV、BKPyV、HHV-6、EBV)感染的影响。IFN-γ+ 874a >在以霉酚酸盐为基础的治疗和移植物失败的患者中，T (IFN产生降低)与巨细胞病毒疾病相关(p = 0.039)。这项研究强调了IFN-γ+874 SNP在CMV感染中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Immunogenetics 医学-免疫学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Immunogenetics (formerly European Journal of Immunogenetics) publishes original contributions on the genetic control of components of the immune system and their interactions in both humans and experimental animals. The term ''genetic'' is taken in its broadest sense to include studies at the evolutionary, molecular, chromosomal functional and population levels in both health and disease. Examples are: -studies of blood groups and other surface antigens- cell interactions and immune response- receptors, antibodies, complement components and cytokines- polymorphism- evolution of the organisation, control and function of immune system components- anthropology and disease associations- the genetics of immune-related disease: allergy, autoimmunity, immunodeficiency and other immune pathologies- All papers are seen by at least two independent referees and only papers of the highest quality are accepted.