Fibrodysplasia Ossificans Progressiva and Pregnancy: A Case Series and Review of the Literature.

IF 0.6 Q4 OBSTETRICS & GYNECOLOGY

Case Reports in Obstetrics and Gynecology Pub Date : 2022-09-16 eCollection Date: 2022-01-01 DOI:10.1155/2022/9857766

Alexandra D Forrest, Danielle M Vuncannon, Jane E Ellis, Zvi Grunwald, Frederick S Kaplan

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引用次数: 1

Abstract

Objective: To evaluate maternal and fetal outcomes in pregnant patients with fibrodysplasia ossificans progressiva (FOP; OMIM#135100), an ultrarare genetic disorder characterized by progressive heterotopic ossification of soft tissues and cumulative disability.

Methods: This is a retrospective case series of three patients with FOP who were admitted to Grady Memorial Hospital in Atlanta, Georgia, from to February 2011 to July 2021.

Results: Three women delivered preterm infants at our institution. These cases posed unique anesthetic and obstetric technical challenges, particularly when securing the airway and performing cesarean delivery. Importantly, each patient received perioperative glucocorticoids for prevention of further heterotopic ossification.

Conclusion: FOP is a unique clinical diagnosis encountered by obstetricians and requires multidisciplinary management for optimal outcomes.

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进行性骨化性纤维发育不良与妊娠:病例系列及文献回顾。

目的:评价进行性骨化性纤维发育不良(FOP;OMIM#135100)是一种罕见的遗传性疾病，其特征是软组织进行性异位骨化和累积性残疾。方法:回顾性分析2011年2月至2021年7月在乔治亚州亚特兰大市格雷迪纪念医院收治的3例FOP患者。结果:3名妇女在我院分娩早产儿。这些病例带来了独特的麻醉和产科技术挑战，特别是在保护气道和实施剖宫产时。重要的是，每位患者围手术期均接受糖皮质激素治疗，以防止进一步异位骨化。结论:FOP是产科医生遇到的一种独特的临床诊断，需要多学科管理才能获得最佳结果。

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