Analysis of the Efficacy and Safety of Intratymapanic Dexamethasone for Treating Meniere's Disease: A Randomized Controlled Trial.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2025-07-01 Epub Date: 2022-09-24 DOI:10.1177/01455613221120729

Gendi Yin, Zhicheng Li, Shuqi Zhang, Xinyi Wang, Jiali Yang, Hao Cai, Xiangli Zeng

{"title":"Analysis of the Efficacy and Safety of Intratymapanic Dexamethasone for Treating Meniere's Disease: A Randomized Controlled Trial.","authors":"Gendi Yin, Zhicheng Li, Shuqi Zhang, Xinyi Wang, Jiali Yang, Hao Cai, Xiangli Zeng","doi":"10.1177/01455613221120729","DOIUrl":null,"url":null,"abstract":"ObjectivesOur objective was to study the efficacy and safety of intratymapanic dexamethasone (ITD) for treating in Méniere's disease in southern China.MethodsA total of 124 patients with Méniere's disease were randomly divided into 2 groups: ITD group (n = 62) and intratympanic lidocaine (ITL) group (n = 62). The ITD group was further randomly divided into 2 groups based on dexamethasone dosage: ITD1 (2 mg/ml) (n = 31) and ITD2 (5 mg/ml) group (n = 31). Symptom alleviation and complications were recorded after every treatment.ResultsVertigo was improved in 65% of patients who received ITD compared with 55% of patients who received ITL patients (P < .05). Three patients in the ITD2 group had from otomycosis, and 2 of these patients had a perforation; no tympanic membrane perforation was observed in the ITL and ITD1 group.ConclusionsCompared with lidocaine, dexamethasone is more effective in alleviating vertigo, and a lower concentration of dexamethasone can reduce the occurrence of complications.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"431-437"},"PeriodicalIF":16.4000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1177/01455613221120729","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/9/24 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

ObjectivesOur objective was to study the efficacy and safety of intratymapanic dexamethasone (ITD) for treating in Méniere's disease in southern China.MethodsA total of 124 patients with Méniere's disease were randomly divided into 2 groups: ITD group (n = 62) and intratympanic lidocaine (ITL) group (n = 62). The ITD group was further randomly divided into 2 groups based on dexamethasone dosage: ITD1 (2 mg/ml) (n = 31) and ITD2 (5 mg/ml) group (n = 31). Symptom alleviation and complications were recorded after every treatment.ResultsVertigo was improved in 65% of patients who received ITD compared with 55% of patients who received ITL patients (P < .05). Three patients in the ITD2 group had from otomycosis, and 2 of these patients had a perforation; no tympanic membrane perforation was observed in the ITL and ITD1 group.ConclusionsCompared with lidocaine, dexamethasone is more effective in alleviating vertigo, and a lower concentration of dexamethasone can reduce the occurrence of complications.

查看原文本刊更多论文

内服地塞米松治疗美尼尔氏病的疗效和安全性分析：随机对照试验

目的：我们的目的是研究在中国南方地区使用日本鼠内地塞米松（ITD）治疗梅尼埃病的有效性和安全性：我们的目的是研究在华南地区使用抗疟药物地塞米松（ITD）治疗梅尼埃病的有效性和安全性：方法：将124名梅尼埃病患者随机分为两组：方法：将124例梅尼埃病患者随机分为两组：ITD组（62例）和鼓室内利多卡因（ITL）组（62例）。ITD 组又根据地塞米松剂量随机分为两组：ITD1（2 毫克/毫升）组（31 人）和 ITD2（5 毫克/毫升）组（31 人）。每次治疗后记录症状缓解情况和并发症：结果：与接受 ITL 治疗的 55% 的患者相比，接受 ITD 治疗的 65% 的患者眩晕症状有所改善（P < .05）。ITD2 组中有 3 名患者患有耳霉菌病，其中 2 名患者出现鼓膜穿孔；而 ITL 和 ITD1 组未发现鼓膜穿孔：结论：与利多卡因相比，地塞米松能更有效地缓解眩晕，而且较低浓度的地塞米松能减少并发症的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.