Diagnostic Accuracy and Relationship Between Optical Coherence Tomography Angiography Vessel Density and Structural/Functional Parameters in Healthy, Preperimetric, and Manifest Glaucoma Eyes.

IF 1.2 Q3 OPHTHALMOLOGY
Journal of Current Ophthalmology Pub Date : 2022-07-26 eCollection Date: 2022-04-01 DOI:10.4103/joco.joco_326_21
Asma Khallouli, Yassin Oueslati, Dhouha Gouider, Saker Bouchoucha, Afef Maalej, Riadh Rannen
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引用次数: 1

Abstract

Purpose: To evaluate circumpapillary vessel density (cpVD) in normal subjects, preperimetric glaucoma, and manifest glaucoma, assess the relationship between cpVD and both structural and functional parameters and compare the diagnostic accuracy of the structural and vascular measurements.

Methods: An analytical cross-sectional study of 153 eyes of 83 individuals divided into three groups: Normal subjects, preperimetric glaucoma, and manifest glaucoma. All individuals underwent standard automated perimetry, spectral-domain optical coherence tomography (SD-OCT), and OCT angiography (OCT-A) centered on the optic nerve. We assessed structural (ganglion cell complex [GCC]/retinal nerve fiber layer [RNFL]) and functional parameters (mean deviation [MD]/loss variance [LV]).

Results: Thirty-three normal subjects (66 eyes), 18 patients (30 eyes) with preperimetric glaucoma, and 32 patients (57 eyes) with manifest primary open-angle glaucoma were enrolled. The comparative study of cpVD showed a significant difference comparing glaucomatous subjects versus preperimetric glaucoma (P = 0.025) groups and normal subjects (P < 0.001). The cpVD was strongly correlated with functional parameters, MD, and LV (P < 0.001). Furthermore, cpVD was better correlated with RNFL (P < 0.001) than GCC (P < 0.001). Best regression was observed with mean RNFL (R2 = 0.752). The cpVD has a higher diagnostic value than RNFL and GCC, only between preperimetric and manifest glaucoma.

Conclusions: Circumpapillary vessel damages seem to be less prominent, as it was seen only for the manifest glaucoma group. Microvascular changes appear to occur secondary to RNFL and GCC damages. They seem to be well correlated with visual function. Therefore, OCT-A is not as sensitive as SD-OCT in detecting early structural alterations.

Abstract Image

Abstract Image

光学相干断层血管造影血管密度和结构/功能参数在健康、预透视和明显青光眼中的诊断准确性和关系
目的:评价正常受试者、周前青光眼和显性青光眼的乳头状血管密度(cpVD),评估cpVD与结构和功能参数的关系,比较结构和血管测量的诊断准确性。方法:对83例患者153只眼进行横断面分析研究,分为3组:正常受试者、周前青光眼和明显青光眼。所有患者都接受了以视神经为中心的标准自动视野检查、光谱域光学相干断层扫描(SD-OCT)和OCT血管造影(OCT- a)。我们评估了结构参数(神经节细胞复合体[GCC]/视网膜神经纤维层[RNFL])和功能参数(平均偏差[MD]/损失方差[LV])。结果:正常人33例(66眼),周前青光眼18例(30眼),原发性开角型青光眼32例(57眼)。青光眼组与术前青光眼组及正常组的cpVD比较,差异有统计学意义(P = 0.025)。cpVD与功能参数、MD、LV密切相关(P < 0.001)。cpVD与RNFL的相关性(P < 0.001)优于GCC (P < 0.001)。平均RNFL回归最佳(R2 = 0.752)。cpVD比RNFL和GCC有更高的诊断价值,仅在术前和明显青光眼之间。结论:乳头周围血管损伤似乎不太突出,因为它只出现在明显青光眼组。微血管变化似乎继发于RNFL和GCC损伤。它们似乎与视觉功能密切相关。因此OCT-A在检测早期结构改变方面不如SD-OCT灵敏。
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来源期刊
CiteScore
2.50
自引率
6.70%
发文量
45
审稿时长
8 weeks
期刊介绍: Peer Review under the responsibility of Iranian Society of Ophthalmology Journal of Current Ophthalmology, the official publication of the Iranian Society of Ophthalmology, is a peer-reviewed, open-access, scientific journal that welcomes high quality original articles related to vision science and all fields of ophthalmology. Journal of Current Ophthalmology is the continuum of Iranian Journal of Ophthalmology published since 1969.
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