The modulatory role of dopamine receptors within the hippocampal cornu ammonis area 1 in stress-induced analgesia in an animal model of persistent inflammatory pain.

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES
Behavioural Pharmacology Pub Date : 2022-10-01 Epub Date: 2022-09-14 DOI:10.1097/FBP.0000000000000697
Ramin Abdi Dezfouli, Pooriya Ghanbari Merdasi, Mina Rashvand, Zahra Mousavi, Abbas Haghparast
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引用次数: 0

Abstract

The intrinsic pain inhibitory mechanisms can be activated by fear, anxiety, and stress. Stressful experiences produce analgesia, referred to as stress-induced analgesia (SIA). Major components of the limbic system, including the ventral tegmental area, nucleus accumbens, amygdala, and hippocampus, are involved in the SIA. In this study, we tried to understand the role of dopamine receptors in the cornu ammonis area 1 (CA1) of the hippocampus in the forced swim stress (FSS)-induced analgesia. Stereotaxic surgery was unilaterally performed on 129 adult male Wistar rats weighing 220-280 g. SCH23390 (0.25, 1, and 4 μg/0.5 μl saline) or sulpiride (0.25, 1, and 4 μg/0.5 μl DMSO), as D1- and D2-like dopamine receptor antagonists, respectively, were microinjected into the CA1 area, 5 min before exposure to FSS for a 6-min period. The vehicle groups received saline or DMSO instead of SCH23390 or sulpiride, respectively. The formalin test was done using formalin injection (50 μl; 2.5%) into the plantar surface of the rat's hind paw immediately after exposure to FSS. The results demonstrated that FSS produces analgesia during the early and late phases of the formalin test. However, intra-CA1 microinjection of SCH23390 or sulpiride attenuated the FSS-induced analgesia in both phases of the formalin test. This study provides new insight into the role of D1- and D2-like dopamine receptors in the CA1 area in the FSS-induced analgesia during persistent inflammatory pain.

海马氨角区1多巴胺受体在持续炎性疼痛动物模型应激性镇痛中的调节作用
内在的疼痛抑制机制可以被恐惧、焦虑和压力激活。应激性经历产生镇痛,称为应激性镇痛(SIA)。边缘系统的主要组成部分,包括腹侧被盖区、伏隔核、杏仁核和海马体,都参与SIA。在本研究中,我们试图了解海马角氨区1 (CA1)多巴胺受体在强迫游泳应激(FSS)诱导的镇痛中的作用。对体重220 ~ 280 g的成年雄性Wistar大鼠129只进行单侧立体定向手术。将SCH23390(0.25、1和4 μg/0.5 μl生理盐水)或舒比利(0.25、1和4 μg/0.5 μl DMSO)分别作为D1和d2样多巴胺受体拮抗剂,在FSS暴露前5分钟微注射于CA1区,持续6分钟。载药组分别用生理盐水或DMSO代替SCH23390或舒必利。福尔马林试验采用福尔马林注射液(50 μl;2.5%)在暴露于FSS后立即进入大鼠后爪足底表面。结果表明,FSS在福尔马林试验的早期和晚期均产生镇痛作用。然而,ca1内显微注射SCH23390或舒必利在福尔马林试验的两个阶段都减弱了fss引起的镇痛。本研究为CA1区D1-和d2样多巴胺受体在持续炎性疼痛中fss诱导的镇痛中的作用提供了新的认识。
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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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