Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine.

IF 4.4 Q1 PATHOLOGY
PATHOLOGICA Pub Date : 2022-08-01 DOI:10.32074/1591-951X-746
Ilaria Girolami, Klaus Eisendle, Reinhard Walther Kluge, Esther Hanspeter, Albino Eccher, Leonardo Vizziello, Pierfrancesco Zampieri, Guido Mazzoleni
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引用次数: 3

Abstract

Skin often represents a target organ for adverse drug reactions and this also applies to the mRNA vaccines against Sars-CoV-2. Here we present a case of extensive livedoid reaction after 2nd dose of BNT162b-2 vaccine with massive blood skin extravasation and no systemic symptoms apart from anemization. The 30-year-old woman developed progressively enlarging livedoid lesions on limbs and abdomen. Histology showed a near-normal epidermis and a very mild interstitial mixed inflammatory infiltrate with extensive blood extravasation in mid- and deep dermis. Diagnosis was adverse reaction to vaccine with skin capillary hyperpermeability and anaemization with lower than diagnostic features of cutaneous small vessel vasculitis. To date, no cases of a livedoid skin reaction associated to Covid-19 vaccine have been reported, and this case illustrates that massive livedoid reaction can be another kind of skin reaction to mRNA Covid-19 vaccine.

Abstract Image

第二剂mRNA - Covid-19疫苗的类活体皮肤反应。
皮肤通常是药物不良反应的靶器官,这也适用于针对Sars-CoV-2的mRNA疫苗。在此,我们报告一例在第二次接种BNT162b-2疫苗后出现广泛的类活体反应,大量血液皮肤外渗,除贫血外无全身症状。这名30岁的女性在四肢和腹部出现了逐渐扩大的活体样病变。组织学表现为表皮接近正常,真皮中深部有非常轻微的间质性混合性炎症浸润,伴大量血液外渗。诊断为疫苗不良反应,皮肤毛细血管通透性高,贫血,低于皮肤小血管炎的诊断特征。到目前为止,尚未报道与新冠病毒疫苗相关的类活体皮肤反应,该病例说明大量类活体皮肤反应可能是mRNA新冠病毒疫苗的另一种皮肤反应。
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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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