Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine.

IF 4.4 Q1 PATHOLOGY
PATHOLOGICA Pub Date : 2022-08-01 DOI:10.32074/1591-951X-746
Ilaria Girolami, Klaus Eisendle, Reinhard Walther Kluge, Esther Hanspeter, Albino Eccher, Leonardo Vizziello, Pierfrancesco Zampieri, Guido Mazzoleni
{"title":"Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine.","authors":"Ilaria Girolami,&nbsp;Klaus Eisendle,&nbsp;Reinhard Walther Kluge,&nbsp;Esther Hanspeter,&nbsp;Albino Eccher,&nbsp;Leonardo Vizziello,&nbsp;Pierfrancesco Zampieri,&nbsp;Guido Mazzoleni","doi":"10.32074/1591-951X-746","DOIUrl":null,"url":null,"abstract":"<p><p>Skin often represents a target organ for adverse drug reactions and this also applies to the mRNA vaccines against Sars-CoV-2. Here we present a case of extensive livedoid reaction after 2nd dose of BNT162b-2 vaccine with massive blood skin extravasation and no systemic symptoms apart from anemization. The 30-year-old woman developed progressively enlarging livedoid lesions on limbs and abdomen. Histology showed a near-normal epidermis and a very mild interstitial mixed inflammatory infiltrate with extensive blood extravasation in mid- and deep dermis. Diagnosis was adverse reaction to vaccine with skin capillary hyperpermeability and anaemization with lower than diagnostic features of cutaneous small vessel vasculitis. To date, no cases of a livedoid skin reaction associated to Covid-19 vaccine have been reported, and this case illustrates that massive livedoid reaction can be another kind of skin reaction to mRNA Covid-19 vaccine.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d1/e6/pathol-2022-04-322.PMC9624132.pdf","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PATHOLOGICA","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32074/1591-951X-746","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 3

Abstract

Skin often represents a target organ for adverse drug reactions and this also applies to the mRNA vaccines against Sars-CoV-2. Here we present a case of extensive livedoid reaction after 2nd dose of BNT162b-2 vaccine with massive blood skin extravasation and no systemic symptoms apart from anemization. The 30-year-old woman developed progressively enlarging livedoid lesions on limbs and abdomen. Histology showed a near-normal epidermis and a very mild interstitial mixed inflammatory infiltrate with extensive blood extravasation in mid- and deep dermis. Diagnosis was adverse reaction to vaccine with skin capillary hyperpermeability and anaemization with lower than diagnostic features of cutaneous small vessel vasculitis. To date, no cases of a livedoid skin reaction associated to Covid-19 vaccine have been reported, and this case illustrates that massive livedoid reaction can be another kind of skin reaction to mRNA Covid-19 vaccine.

Abstract Image

第二剂mRNA - Covid-19疫苗的类活体皮肤反应。
皮肤通常是药物不良反应的靶器官,这也适用于针对Sars-CoV-2的mRNA疫苗。在此,我们报告一例在第二次接种BNT162b-2疫苗后出现广泛的类活体反应,大量血液皮肤外渗,除贫血外无全身症状。这名30岁的女性在四肢和腹部出现了逐渐扩大的活体样病变。组织学表现为表皮接近正常,真皮中深部有非常轻微的间质性混合性炎症浸润,伴大量血液外渗。诊断为疫苗不良反应,皮肤毛细血管通透性高,贫血,低于皮肤小血管炎的诊断特征。到目前为止,尚未报道与新冠病毒疫苗相关的类活体皮肤反应,该病例说明大量类活体皮肤反应可能是mRNA新冠病毒疫苗的另一种皮肤反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信