Deep brain stimulation of the subthalamic nucleus for epilepsy

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Acta Neurologica Scandinavica Pub Date : 2022-09-22 DOI:10.1111/ane.13707

Hao Yan, Liankun Ren, Tao Yu

引用次数: 5

Abstract

Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a promising palliative option for patients with refractory epilepsy. However, crucial questions remain unanswered: Which patients are the optimal candidates? How, where, and when to stimulate the STN? And what is the mechanism of STN-DBS action on epilepsy? Thus, we reviewed the clinical evidence on the antiepileptic effects of STN-DBS and its possible mechanisms on drug-resistant epilepsy, its safety, and the factors influencing stimulation outcomes. This information may guide clinical decision-making. In addition, based on the current knowledge on the effect of STN-DBS on epilepsy, we suggest research that needs to be carried out in the future.

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丘脑下核深部脑刺激治疗癫痫

丘脑下核深部脑刺激(STN-DBS)是难治性癫痫患者的一种有希望的姑息治疗选择。然而，关键问题仍未得到解答:哪些患者是最佳人选?如何、在何处、何时刺激STN?STN-DBS对癫痫的作用机制是什么?因此，我们就STN-DBS抗癫痫作用及其对耐药癫痫的可能机制、安全性以及刺激结果的影响因素等方面的临床证据进行综述。这些信息可以指导临床决策。此外，基于目前对STN-DBS对癫痫的作用的了解，我们建议未来需要开展的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neurologica Scandinavica 医学-临床神经学

CiteScore

6.70

自引率

2.90%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Acta Neurologica Scandinavica aims to publish manuscripts of a high scientific quality representing original clinical, diagnostic or experimental work in neuroscience. The journal''s scope is to act as an international forum for the dissemination of information advancing the science or practice of this subject area. Papers in English will be welcomed, especially those which bring new knowledge and observations from the application of therapies or techniques in the combating of a broad spectrum of neurological disease and neurodegenerative disorders. Relevant articles on the basic neurosciences will be published where they extend present understanding of such disorders. Priority will be given to review of topical subjects. Papers requiring rapid publication because of their significance and timeliness will be included as ''Clinical commentaries'' not exceeding two printed pages, as will ''Clinical commentaries'' of sufficient general interest. Debate within the speciality is encouraged in the form of ''Letters to the editor''. All submitted manuscripts falling within the overall scope of the journal will be assessed by suitably qualified referees.