Long-term effects of methamphetamine abuse on visual evoked potentials.

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) Pub Date : 2022-11-01 Epub Date: 2022-09-12 DOI:10.1111/opo.13048

Monireh Mahjoob, Samira Heydarian

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引用次数: 1

Abstract

Purpose: To compare visual evoked potential (VEP) components in normal individuals and those with long-term methamphetamine and crystal methamphetamine use.

Methods: In this study, monocular pattern-reversal VEPs were recorded in 40 methamphetamine and crystal methamphetamine users and 38 normal individuals. Visual stimuli were high-contrast (99%) checkerboard patterns at 15 and 60 min of arc with a reversal rate of 1.53 reversals per second.

Results: A significant difference was seen between the two groups for the P100 peak time for the 60 min of arc checks (p = 0.002, d = 0.75, 4.61% higher peak time in the addicted group) and the 15 min of arc checks (p = 0.004, d = 0.73, 4.78% higher peak time in the addicted group). However, other VEP components were not significantly different between the two groups.

Conclusions: The higher P100 peak time at both 15 and 60 min of arc in methamphetamine-dependent users reveals that VEPs are highly sensitive for the diagnosis of retinal and visual pathway lesions.

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甲基苯丙胺滥用对视觉诱发电位的长期影响。

目的:比较正常人与长期使用冰毒和冰毒晶体者的视觉诱发电位(VEP)成分。方法:对40例甲基苯丙胺和晶体甲基苯丙胺服用者和38例正常人进行单眼模式逆转vep记录。视觉刺激是高对比度(99%)棋盘图案，在15和60分钟的弧度，反转率为1.53次/秒。结果:两组在60 min测弧时P100峰值时间(p = 0.002, d = 0.75，成瘾组峰值时间高4.61%)和15 min测弧时P100峰值时间(p = 0.004, d = 0.73，成瘾组峰值时间高4.78%)差异均有统计学意义。然而，其他VEP成分在两组之间无显著差异。结论:甲基苯丙胺依赖者在15和60 min的P100峰值时间较高，表明vep对视网膜和视觉通路病变的诊断高度敏感。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

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