Nanoemulsion and Nanogel Containing Eucalyptus globulus Essential Oil; Larvicidal Activity and Antibacterial Properties.

Q3 Immunology and Microbiology

Interdisciplinary Perspectives on Infectious Diseases Pub Date : 2022-08-31 eCollection Date: 2022-01-01 DOI:10.1155/2022/1616149

Hiva Alipanah, Abbas Abdollahi, Samira Firooziyan, Elham Zarenezhad, Mojtaba Jafari, Mahmoud Osanloo

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Abstract

Eucalyptus globulus essential oil (EGEO) possesses many biological effects such as antibacterial, antifungal, and insecticide properties. In the current study, the chemical composition of EGEO was first investigated using GC-MS analysis. Then, a nanoemulsion and nanogel containing EGEO (EGEO-nanoemulsion and EGEO-nanogel) were prepared. After that, the successful loading of EGEO was confirmed using ATR-FTIR analysis. EGEO-nanoemulsion and EGEO-nanogel with LC₅₀ values of 27 and 32 μg/mL showed promising efficacies against Anopheles stephensi larvae. Besides, the efficacy of EGEO-nanogel (IC₅₀ 187 μg/mL) was significantly more potent than EGEO-nanoemulsion (IC₅₀ 3732 μg/mL) against Staphylococcus aureus. However, no significant difference was observed in the efficacy of EGEO-nanoemulsion and EGEO-nanogel against Pseudomonas aeruginosa. Natural components, straightforward preparation, and proper efficacy are some of the advantages of EGEO-nanogel; it could be considered for further consideration against other pathogens and mosquito larvae.

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含有蓝桉精油的纳米乳液和纳米凝胶；杀幼虫活性和抗菌特性。

蓝桉精油（EGEO）具有抗菌、抗真菌和杀虫等多种生物功效。在本研究中，首先使用气相色谱-质谱分析法研究了 EGEO 的化学成分。然后，制备了含有 EGEO 的纳米乳液和纳米凝胶（EGEO-纳米乳液和 EGEO-纳米凝胶）。之后，利用 ATR-FTIR 分析法确认了 EGEO 的成功负载。EGEO 纳米乳液和 EGEO 纳米凝胶的半致死浓度分别为 27 和 32 μg/mL，对按蚊幼虫具有良好的药效。此外，EGEO 纳米凝胶（IC50 187 μg/mL）对金黄色葡萄球菌的药效明显高于 EGEO 纳米乳液（IC50 3732 μg/mL）。但 EGEO 纳米乳液和 EGEO 纳米凝胶对铜绿假单胞菌的药效没有明显差异。EGEO 纳米凝胶具有成分天然、制备简单、药效适当等优点，可进一步考虑用于抗击其他病原体和蚊子幼虫。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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