Mild thermal stimulation of the buttock skin increases urinary voiding efficiency in anesthetized rats

IF 3.2 4区医学 Q2 NEUROSCIENCES

Autonomic Neuroscience-Basic & Clinical Pub Date : 2022-11-01 DOI:10.1016/j.autneu.2022.103022

Kaori Iimura, Nobuhiro Watanabe, Harumi Hotta

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Abstract

In the present study, we examined the effects of mild thermal stimulation of the skin on voiding efficiency using urethane-anesthetized rats with reduced voiding efficiency. Spontaneous urination was induced by infusing saline. For each voiding, the voiding efficiency was calculated from the voided volume and the bladder capacity measured. A Peltier thermode was attached to the buttock skin to apply stimulation: cooling between to 25 °C and 35 °C, every 20 s throughout the saline infusion. The voiding efficiency was 29 ± 9 % (mean ± SD) before stimulation and increased significantly by 10–15 % during stimulation. During thermal stimulation, the maximum vesical pressure during micturition was unchanged, but the urethral relaxation duration was significantly prolonged. Applying local anesthesia to the stimulated skin area abolished the changes in voiding efficiency in response to thermal stimulation. These results suggest that the excitation of cutaneous thermoreceptive afferents modulates urethral function during urination, thereby improving voiding efficiency.

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对麻醉大鼠臀部皮肤进行轻度热刺激可提高排尿效率

在本研究中，我们研究了皮肤轻度热刺激对尿道麻醉大鼠排尿效率的影响。经生理盐水输注诱导自然排尿。每次排尿时，根据排尿量和膀胱容量计算排尿效率。将珀尔帖热模贴在臀部皮肤上进行刺激:在生理盐水输注过程中每20秒冷却至25°C至35°C。增产前排尿效率为29±9%(平均±SD)，增产后排尿效率显著提高10 - 15%。热刺激时排尿时膀胱最大压力不变，但尿道松弛时间明显延长。在受刺激的皮肤区域局部麻醉可以消除热刺激引起的排尿效率的变化。这些结果表明，在排尿过程中，皮肤热感受传入神经的兴奋可以调节尿道功能，从而提高排尿效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autonomic Neuroscience-Basic & Clinical 医学-神经科学

CiteScore

5.80

自引率

7.40%

发文量

审稿时长

66 days

期刊介绍： This is an international journal with broad coverage of all aspects of the autonomic nervous system in man and animals. The main areas of interest include the innervation of blood vessels and viscera, autonomic ganglia, efferent and afferent autonomic pathways, and autonomic nuclei and pathways in the central nervous system. The Editors will consider papers that deal with any aspect of the autonomic nervous system, including structure, physiology, pharmacology, biochemistry, development, evolution, ageing, behavioural aspects, integrative role and influence on emotional and physical states of the body. Interdisciplinary studies will be encouraged. Studies dealing with human pathology will be also welcome.