Deficient Lmna in fibroblasts: an emerging role of non-cardiomyocytes in DCM.

Abstract

LMNA gene encodes intermediate filament proteins Lamin A/C. Lamin A and Lamin C polymerize to form nuclear lamina, mainly located in the inner layer of the nuclear envelope. As an essential component of the nuclear envelope, Lamins are necessary for nuclear structural integrity and participate in chromatin organization, cell cycle regulation, and DNA damage response [1] . By far, LMNA has the largest and most