Outstanding Features of COVID-19 Overlapping Primary Immunodeficiency in Children.

Abstract

https://immunenetwork.org Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2, is a highly transmittable and contagious infection among the general population, especially in individuals with immune defects regardless of primary immunodeficiencies (PID) or secondary immunodeficiencies caused by infectious agents and drugs. PID, caused by genetic defects, is referred to the inability to produce a normal complement of Abs or immunologically sensitized T cells especially in response to specific Ags. Registry and survey data from a variety of sources reveal an incidence for all PID ranging from 1 in 10,000 to 1 in 2,000 live births. Individual PID may be rare, but altogether, they are exactly frequent. Admittedly, little is known, to date, about the clinical features of COVID-19 overlapping PID.