Multiple exposure distributed lag models with variable selection.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Joseph Antonelli, Ander Wilson, Brent A Coull
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引用次数: 0

Abstract

Distributed lag models are useful in environmental epidemiology as they allow the user to investigate critical windows of exposure, defined as the time periods during which exposure to a pollutant adversely affects health outcomes. Recent studies have focused on estimating the health effects of a large number of environmental exposures, or an environmental mixture, on health outcomes. In such settings, it is important to understand which environmental exposures affect a particular outcome, while acknowledging the possibility that different exposures have different critical windows. Further, in studies of environmental mixtures, it is important to identify interactions among exposures and to account for the fact that this interaction may occur between two exposures having different critical windows. Exposure to one exposure early in time could cause an individual to be more or less susceptible to another exposure later in time. We propose a Bayesian model to estimate the temporal effects of a large number of exposures on an outcome. We use spike-and-slab priors and semiparametric distributed lag curves to identify important exposures and exposure interactions and discuss extensions with improved power to detect harmful exposures. We then apply these methods to estimate the effects of exposure to multiple air pollutants during pregnancy on birthweight from vital records in Colorado.

带有变量选择的多重暴露分布式滞后模型。
分布式滞后模型在环境流行病学中非常有用,因为它允许用户调查暴露的临界窗口,即暴露于污染物对健康结果产生不利影响的时间段。最近的研究侧重于估算大量环境暴露或环境混合物对健康结果的影响。在这种情况下,重要的是了解哪些环境暴露会影响特定的结果,同时承认不同的暴露可能有不同的临界窗口。此外,在对环境混合物的研究中,重要的是要确定暴露之间的相互作用,并考虑到这种相互作用可能发生在具有不同临界窗口的两种暴露之间。早期暴露于一种暴露可能会导致个体在后期对另一种暴露的易感性增大或减小。我们提出了一种贝叶斯模型来估计大量暴露对结果的时间影响。我们使用尖峰和平板先验以及半参数分布滞后曲线来识别重要的暴露和暴露相互作用,并讨论了提高检测有害暴露能力的扩展方法。然后,我们将这些方法应用于根据科罗拉多州的生命记录估算孕期暴露于多种空气污染物对出生体重的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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