Frequency and intensity of [18F]-PSMA-1007 uptake after COVID-19 vaccination in clinical PET.

BJR open Pub Date : 2022-02-01 eCollection Date: 2022-01-01 DOI:10.1259/bjro.20210084
Alexander Maurer, Helen Schiesser, Stephan Skawran, Antonio G Gennari, Manuel Dittli, Irene A Burger, Cäcilia Mader, Christoph Berger, Daniel Eberli, Martin W Huellner, Michael Messerli
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引用次数: 2

Abstract

Objectives: To assess the frequency and intensity of [18F]-prostate-specific membrane antigen (PSMA)-1007 axillary uptake in lymph nodes ipsilateral to COVID-19 vaccination with BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna) in patients with prostate cancer referred for oncological [18F]-PSMA positron emission tomography (PET)/CT or PET/MR imaging.

Methods: 126 patients undergoing [18F]-PSMA PET/CT or PET/MR imaging were retrospectively included. [18F]-PSMA activity (maximum standardized uptake value) of ipsilateral axillary lymph nodes was measured and compared with the non-vaccinated contralateral side and with a non-vaccinated negative control group. [18F]-PSMA active lymph node metastases were measured to serve as quantitative reference.

Results: There was a significant difference in maximum standardized uptake value in ipsilateral and compared to contralateral axillary lymph nodes in the vaccination group (n = 63, p < 0.001) and no such difference in the non-vaccinated control group (n = 63, p = 0.379). Vaccinated patients showed mildly increased axillary lymph node [18F]-PSMA uptake as compared to non-vaccinated patients (p = 0.03). [18F]-PSMA activity of of lymph node metastases was significantly higher (p < 0.001) compared to axillary lymph nodes of vaccinated patients.

Conclusion: Our data suggest mildly increased [18F]-PSMA uptake after COVID-19 vaccination in ipsilateral axillary lymph nodes. However, given the significantly higher [18F]-PSMA uptake of prostatic lymph node metastases compared to "reactive" nodes after COVID-19 vaccination, no therapeutic and diagnostic dilemma is to be expected.

Advances in knowledge: No specific preparations or precautions (e.g. adaption of vaccination scheduling) need to be undertaken in patients undergoing [18F]-PSMA PET imaging after COVID-19 vaccination.

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临床PET中COVID-19疫苗接种后[18F]-PSMA-1007摄取的频率和强度。
目的:评估在转诊进行肿瘤[18F]-PSMA正电子发射断层扫描(PET)/CT或PET/MR成像的前列腺癌患者中,接种BNT162b2(辉瑞- biontech)或mRNA-1273 (Moderna)的COVID-19疫苗同侧淋巴结腋下摄取[18F]-前列腺特异性膜抗原(PSMA)-1007的频率和强度。方法:回顾性分析126例接受[18F]-PSMA PET/CT或PET/MR成像的患者。[18F]测量同侧腋窝淋巴结的psma活性(最大标准化摄取值),并与未接种疫苗的对侧和未接种疫苗的阴性对照组进行比较。[18F]测定-PSMA活动性淋巴结转移作为定量参考。结果:接种组同侧腋窝淋巴结最大标准化摄取值与对侧腋窝淋巴结比较差异有统计学意义(n = 63, p < 0.001),未接种组腋窝淋巴结最大标准化摄取值无统计学意义(n = 63, p = 0.379)。与未接种疫苗的患者相比,接种疫苗的患者腋窝淋巴结[18F]-PSMA摄取轻度增加(p = 0.03)。[18F]与接种疫苗患者腋窝淋巴结相比,淋巴结转移灶的psma活性显著升高(p < 0.001)。结论:我们的数据表明,接种COVID-19后,同侧腋窝淋巴结的[18F]-PSMA摄取轻度增加。然而,鉴于与COVID-19疫苗接种后的“反应性”淋巴结相比,前列腺淋巴结转移的[18F]-PSMA摄取明显更高,因此预计不会出现治疗和诊断困境。知识进步:在COVID-19疫苗接种后接受[18F]-PSMA PET成像的患者无需采取特定的准备或预防措施(例如调整疫苗接种计划)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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