The aryl hydrocarbon receptor: a review of its role in the physiology and pathology of the integument and its relationship to the tryptophan metabolism.

IF 2.7 Q3 NEUROSCIENCES

International Journal of Tryptophan Research Pub Date : 2015-02-10 eCollection Date: 2015-01-01 DOI:10.4137/IJTR.S19985

Rowland Noakes

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引用次数: 57

Abstract

The aryl hydrocarbon receptor (AHR) is a cytosolic receptor for low molecular weight molecules, of which the most widely recognized ligand is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and the most widely recognized effect, chloracne. Adverse effects of manipulation were most recently and graphically demonstrated by the poisoning of Viktor Yushchenko during the Ukrainian presidential elections of 2004. However, recent research has revealed a receptor with wide-ranging, and at times, paradoxical actions. It was arguably among the first biological receptors to be utilized by dermatologists, dating from the time of topical tar preparations as a therapeutic agent. I provide a review outlining the role AHR plays in the development, cellular oxidation/antioxidation, responses to ultraviolet light, melanogenesis, epidermal barrier function, and immune regulation and its relationship to tryptophan metabolism. Finally, I will review the role of AHR in diseases of the integument.

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芳烃受体:综述其在被膜生理和病理中的作用及其与色氨酸代谢的关系。

芳烃受体(AHR)是一种低分子量分子的细胞质受体，其中最广泛认识的配体是2,3,7,8-四氯二苯并-对二恶英(TCDD)，最广泛认识的效应是氯痤英。2004年乌克兰总统选举期间，维克托•尤先科(Viktor Yushchenko)中毒事件生动地证明了操纵的负面影响。然而，最近的研究揭示了一种受体具有广泛的，有时是矛盾的作用。它可以说是皮肤科医生使用的第一批生物受体之一，可以追溯到局部焦油制剂作为治疗剂的时代。本文综述了AHR在发育、细胞氧化/抗氧化、紫外线反应、黑色素生成、表皮屏障功能、免疫调节及其与色氨酸代谢的关系等方面的作用。最后，我将回顾AHR在外皮疾病中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Tryptophan Research NEUROSCIENCES-

CiteScore

7.30

自引率

4.50%

发文量

审稿时长

8 weeks