Development of an acetate ion-assisted POP bond formations to access tetraalkyl pyrophosphates

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2023-04-28 DOI:10.1016/j.tetlet.2023.154456

Min Zhang , Dumei Ma , Jianxi Ying , Yufen Zhao

引用次数: 0

Abstract

Pyrophosphates having P(O)-OP(O) linkages are of interest as biologically active substances. However, only a few research had been focused on POP formation to furnish pyrophosphate. Here, we first developed acetate ion‐assisted POP bond formations using H-Phosphonates as substrates to obtain tetraalkyl pyrophosphates. The reaction mechanism was traced by NMR experiments, revealing that the acetate ion is engaged in the formation of POP bond.

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醋酸离子辅助POP键形成以获取四烷基焦磷酸盐

具有P(O)-OP(O)键的焦磷酸盐作为生物活性物质而受到关注。然而，目前对POP形成提供焦磷酸盐的研究较少。在这里，我们首先开发了醋酸离子辅助的POP键形成，使用h -膦酸盐作为底物来获得四烷基焦磷酸盐。通过核磁共振实验对反应机理进行了追踪，发现醋酸离子参与了POP键的形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.