Iontophoretic delivery of riboflavin into the rabbit cornea: a primary study.

眼科学报 Pub Date : 2014-03-01

Na Li, Xiujun Peng, Zhengjun Fan, Yu Xia

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引用次数: 0

Abstract

Purpose: To determine the penetrability of riboflavin into the corneal stroma by iontophoresis and to compare the permeability effects of different solvents.

Methods: Twenty rabbits were randomly divided into four groups: a group that received 0.1% riboflavin-balanced salt solution (BSS) by iontophoresis, a group that received 0.1% riboflavin-saline solution by iontophoresis, a group that received 0.1% riboflavin-distilled water solution by iontophoresis, and a control group that received classical riboflavin instillation after corneal de-epithelialization. The degree of yellowing of the de-epithelialized corneal stromal button from each rabbit was compared.

Results: The yellow color scores for the corneal stromal buttons in the three iontophoresis groups were compared with those of control group. Iontophoretic delivery of a 0.1% riboflavin-distilled water solution yielded similar yellow changes in the corneal stromal button when compared with classical riboflavin instillation after de-epithelialization. However, the other two solvents did not sufficiently enhance the permeability of riboflavin.

Conclusion: Riboflavin can effectively penetrate into the corneal stroma to saturation levels by iontophoresis. Using distilled water as the solvent can promote penetrability.

本刊更多论文

核黄素离子电泳进入兔角膜的初步研究。

目的:用离子透入法测定核黄素对角膜基质的透入性，比较不同溶剂对核黄素透入性的影响。方法:将20只家兔随机分为4组:离子导入0.1%核黄素平衡盐溶液组(BSS)、离子导入0.1%核黄素-生理盐水组(BSS)、离子导入0.1%核黄素-蒸馏水组(BSS)、角膜去上皮化后经典核黄素灌注组(对照组)。比较各组去上皮角膜基质钮扣的黄化程度。结果:三个离子导入组的角膜间质扣黄色评分与对照组比较。在去上皮化后，与传统的核黄素滴注相比，0.1%核黄素蒸馏水溶液的离子电泳递送在角膜基质钮扣中产生了类似的黄色变化。而其他两种溶剂均不能充分增强核黄素的通透性。结论:核黄素可通过离子导入有效渗透到角膜基质至饱和水平。使用蒸馏水作为溶剂可以提高渗透性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

眼科学报

自引率

0.00%

发文量

1312

期刊介绍： Eye science was founded in 1985. It is a national medical journal supervised by the Ministry of Education of the People's Republic of China, sponsored by Sun Yat-sen University, and hosted by Sun Yat-sen University Zhongshan Eye Center (in October 2020, it was changed from a quarterly to a monthly, with the publication number: ISSN: 1000-4432; CN: 44-1119/R). It is edited by Ge Jian, former dean of Sun Yat-sen University Zhongshan Eye Center, Liu Yizhi, director and dean of Sun Yat-sen University Zhongshan Eye Center, and Lin Haotian, deputy director of Sun Yat-sen University Zhongshan Eye Center, as executive editor. It mainly reports on new developments and trends in the field of ophthalmology at home and abroad, focusing on basic research in ophthalmology, clinical experience, and theoretical knowledge and technical operations related to epidemiology. It has been included in important databases at home and abroad, such as Chemical Abstract (CA), China Journal Full-text Database (CNKI), China Core Journals (Selection) Database (Wanfang), and Chinese Science and Technology Journal Database (VIP).