Nodular pulmonary amyloidosis--rare cause of calcified pulmonary nodules.

Q4 Medicine
Pneumologia Pub Date : 2015-01-01
Anca Macri, Radu Matache, Diana Leonte, Radu Stoica
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引用次数: 0

Abstract

The article presents the case of a 60-year-old asymptomatic woman whose chest X-ray screening showed bilateral pulmonary nodules of uncertain etiology. Initially, the main suspicion concerned multiple pulmonary metastases, but the anatomical pathology examination of two of the surgically removed lung nodules revealed a benign pattern--foreign body granulomatous reaction to cholesterol crystals. Patient follow-up with a repeat computed tomography one year later showed that some pulmonary nodules had slightly increased in number and size, so the diagnosis required re-evaluation. Congo red staining revealed a positive reaction in the amorphous material, pointing to a nodular form of pulmonary amyloidosis. This case attests to the wide range of investigations needed to examine multiple pulmonary nodules and to the great variety of possible diagnoses. Surgical biopsy, alongside histopathological examination and immunohistochemical tests of the lung are critical in establishing a positive diagnosis. Pulmonary amyloidosis requires additional investigations and long-term follow-up of the patient, as this condition is frequently associated with MALT (mucosa-associated lymphoid tissue) lymphoma or multiple myeloma.

结节性肺淀粉样变——肺结节钙化的罕见病因。
本文提出的情况下,60岁无症状的妇女胸部x线检查显示双侧肺结节不明病因。最初,主要怀疑是多发性肺转移,但手术切除的两个肺结节的解剖病理检查显示为良性模式-胆固醇晶体的异物肉芽肿反应。一年后患者复查计算机断层扫描显示,一些肺结节的数量和大小略有增加,因此需要重新评估诊断。刚果红染色显示无定形物质呈阳性反应,提示结节状肺淀粉样变性。这个病例证明了在检查多发肺结节时需要广泛的调查和多种可能的诊断。手术活检,以及组织病理学检查和肺免疫组织化学测试是建立阳性诊断的关键。肺淀粉样变需要额外的检查和患者的长期随访,因为这种情况通常与MALT(粘膜相关淋巴组织)淋巴瘤或多发性骨髓瘤相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pneumologia
Pneumologia Medicine-Pulmonary and Respiratory Medicine
CiteScore
0.20
自引率
0.00%
发文量
10
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