Expression of 52-kDa FK506-binding protein (FKBP52) in human placenta complicated by preeclampsia and intrauterine growth restriction.

IF 0.1 4区医学 Q4 Medicine

Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2015-04-01

Nuray Acar, Ismail Ustunel

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引用次数: 0

Abstract

Objective: To investigate the expression of 52-kDa FK506-binding protein (FKBP52) in human placentas complicated by preeclampsia (PE) and intrauterine growth restriction (IUGR).

Study design: Case-control study including placentas from 6 PE pregnancies, 6 IUGR pregnancies, and 6 controls. FKBP52 expression was determined by immunohistochemistry and Western blot techniques.

Results: FKBP52 expression was downregulated in PE group placentas compared to control and IUGR group placentas. In IUGR group placentas FKBP52 expression was upregulated compared to control and PE group placentas. FKBP52 expression differences between PE and IUGR group placentas (p = 0.008) and control and IUGR group placentas (p = 0.042) were statistically significant. There was FKBP52 immunoreactivity in decidua, syncytiotrophoblast, villous stromal cells, and vascular endothelium in all groups. Unlike control and PE group placentas, FKBP52 expression was continuous in syncytiotrophoblast of IUGR group placentas.

Conclusion: FKBP52 seems to be disrupted in PE and IUGR pregnancies. Decrease of FKBP52 protein levels in PE and increase in IUGR group placentas might have an importance and be involved in the pathogenesis of PE and IUGR.

本刊更多论文

52-kDa fk506结合蛋白(FKBP52)在人胎盘合并子痫前期和宫内生长受限患者中的表达

目的:探讨52-kDa fk506结合蛋白(FKBP52)在人胎盘合并子痫前期(PE)和宫内生长受限(IUGR)中的表达。研究设计:病例对照研究，包括6例PE妊娠、6例IUGR妊娠和6例对照组的胎盘。采用免疫组织化学和Western blot技术检测FKBP52的表达。结果:与对照组和IUGR组相比，PE组胎盘中FKBP52表达下调。与对照组和PE组相比，IUGR组胎盘FKBP52表达上调。FKBP52在PE组和IUGR组胎盘(p = 0.008)与对照组和IUGR组胎盘(p = 0.042)的表达差异均有统计学意义。各组蜕膜、合胞滋养细胞、绒毛间质细胞和血管内皮均有FKBP52免疫反应。与对照组和PE组胎盘不同，IUGR组胎盘合体滋养细胞中FKBP52的表达是连续的。结论:在PE和IUGR妊娠中，FKBP52可能被破坏。PE组胎盘FKBP52蛋白水平的降低和IUGR组胎盘FKBP52蛋白水平的升高可能在PE和IUGR的发病机制中起重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Analytical and Quantitative Cytopathology and Histopathology CELL BIOLOGY-

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： AQCH is an Official Periodical of The International Academy of Cytology and the Italian Society of Urologic Pathology.