[Evolution of mechanisms of Ca(2+)-signaling. Role of Ca2+ in regulation of specialized functions of cardiomyocytes in chronic heart diseases].

Abstract

The review considers role of Ca2+ ions in regulation of specialized functions of cardiomyocytes (CM) in disturbances of heart activity. Problems of Ca(2+)-dependent signaling mechanisms leading to pathological hypertrophy, arrythmogenesis, and heart failure are elucidated. A particular attention is paid to analysis of Ca(2+)-dependent molecular mechanisms leading to remodeling of contractile proteins, apoptosis, or pathological growth of CM.