P Ravi Kumar, Manoranjan Behera, M Sambaiah, Venu Kandula, Nagaraju Payili, A Jaya Shree, Satyanarayana Yennam
{"title":"Design and synthesis of novel isoxazole tethered quinone-amino Acid hybrids.","authors":"P Ravi Kumar, Manoranjan Behera, M Sambaiah, Venu Kandula, Nagaraju Payili, A Jaya Shree, Satyanarayana Yennam","doi":"10.1155/2014/721291","DOIUrl":null,"url":null,"abstract":"<p><p>A new series of isoxazole tethered quinone-amino acid hybrids has been designed and synthesized involving 1,3-dipolar cycloaddition reaction followed by an oxidation reaction using cerium ammonium nitrate (CAN). Using this method, for the first time various isoxazole tethered quinone-phenyl alanine and quinone-alanine hybrids were synthesized from simple commercially available 4-bromobenzyl bromide, propargyl bromide, and 2,5-dimethoxybenzaldehyde in good yield. </p>","PeriodicalId":14901,"journal":{"name":"Journal of Amino Acids","volume":"2014 ","pages":"721291"},"PeriodicalIF":0.0000,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/721291","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Amino Acids","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2014/721291","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2014/11/19 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
A new series of isoxazole tethered quinone-amino acid hybrids has been designed and synthesized involving 1,3-dipolar cycloaddition reaction followed by an oxidation reaction using cerium ammonium nitrate (CAN). Using this method, for the first time various isoxazole tethered quinone-phenyl alanine and quinone-alanine hybrids were synthesized from simple commercially available 4-bromobenzyl bromide, propargyl bromide, and 2,5-dimethoxybenzaldehyde in good yield.
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