Emergency surgery for metastatic melanoma.

IF 1.6 Q4 ONCOLOGY
International Journal of Surgical Oncology Pub Date : 2014-01-01 Epub Date: 2014-10-28 DOI:10.1155/2014/987170
Dimitrios Mantas, Petros Tsaparas, Petros Charalampoudis, Helen Gogas, Gregory Kouraklis
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引用次数: 8

Abstract

Visceral metastases from malignant melanoma (stage M1c) confer a very poor prognosis, as documented on the most recent revised version of the TNM/AJCC staging system. Emergency surgery for intra-abdominal complications from the disease is rare. We report on our 5-year single institution experience with surgical management of metastatic melanoma to the viscera in the emergent setting. From 2009 to 2013, 14 patients with metastatic melanoma were admitted emergently due to an acute abdomen. Clinical manifestations encompassed intestinal obstruction and bleeding. Surgical procedures involved multiple enterectomies with primary anastomoses in 8 patients, and one patient underwent splenectomy, one adrenalectomy, one right colectomy, one gastric wedge resection, one gastrojejunal anastomosis, and one transanal debulking, respectively. The 30-day mortality was 7 percent. Median follow-up was 14 months. Median overall survival was 14 months. Median disease free survival was 7.5 months. One-year overall survival was 64.2 percent and 2-year overall survival was 14.2 percent. Emergency surgery for metastatic melanoma to the viscera is rare. Elective curative surgery combined with novel cytotoxic systemic therapies is under investigation in an attempt to grant survival benefit in melanoma patients with visceral disease.

转移性黑色素瘤的紧急手术
根据最新修订的TNM/AJCC分期系统,恶性黑色素瘤(M1c期)的内脏转移预后非常差。急诊手术治疗腹腔并发症的疾病是罕见的。我们报告我们5年的单一机构经验,转移性黑色素瘤的手术管理到内脏在紧急情况下。从2009年到2013年,14例转移性黑色素瘤患者因急腹症被紧急收治。临床表现包括肠梗阻和出血。8例患者行多处肠切除术并一期吻合,1例患者分别行脾切除术、肾上腺切除术、右结肠切除术、胃楔形切除术、胃空肠吻合术和经肛门减压术。30天死亡率为7%。中位随访时间为14个月。中位总生存期为14个月。中位无病生存期为7.5个月。1年总生存率为64.2%,2年总生存率为14.2%。紧急手术治疗转移到内脏的黑色素瘤是罕见的。选择性治疗性手术联合新型细胞毒性全身疗法正在研究中,试图提高黑色素瘤合并内脏疾病患者的生存率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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