Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix.

IF 4.9 Q2 NANOSCIENCE & NANOTECHNOLOGY
Nanotechnology, Science and Applications Pub Date : 2014-12-01 eCollection Date: 2014-01-01 DOI:10.2147/NSA.S72083
Nichrous Mlalila, Hulda Swai, Lonji Kalombo, Askwar Hilonga
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引用次数: 16

Abstract

The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100 mg of stearic acid, 2% and 3% w/v polyvinyl alcohol, 5% w/v lactose, and 0.2% w/v chitosan. The emulsions were immediately spray-dried based on an optimized model of inlet temperature and pump rate, and characterized for optimized responses with regard to particle size, polydispersity index, and zeta potential, for both emulsion and powder samples. Dynamic light scattering analysis shown that the nanoparticles increased in size with increasing concentrations of polyvinyl alcohol and stearic acid. Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry. These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use.

Abstract Image

Abstract Image

喷雾干燥对硬脂酸基质制备w/o/w复合乳剂的影响。
本研究的目的是探讨喷雾干燥对装载硬脂酸基质的w/o/w双甲基睾酮乳剂(MT)的影响。以硬脂酸50、75和100 mg,聚乙烯醇2%和3% w/v,乳糖5% w/v,壳聚糖0.2% w/v为原料,采用油包水乳液技术制备了载mt纳米颗粒。根据优化的入口温度和泵速模型,对乳液进行喷雾干燥,并对乳液和粉末样品的粒径、多分散性指数和zeta电位进行优化。动态光散射分析表明,随着聚乙烯醇和硬脂酸浓度的增加,纳米颗粒的尺寸增大。扫描电镜显示,负载mt的纳米颗粒呈球形,表面光滑,呈非晶态,差示扫描量热法证实了这一点。这些负载MT的纳米颗粒是一种很有前途的MT递送载体;但是,为了确定系统的稳定性和正常使用条件下的货物释放情况,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nanotechnology, Science and Applications
Nanotechnology, Science and Applications NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
11.70
自引率
0.00%
发文量
3
审稿时长
16 weeks
期刊介绍: Nanotechnology, Science and Applications is an international, peer-reviewed, Open Access journal that focuses on the science of nanotechnology in a wide range of industrial and academic applications. The journal is characterized by the rapid reporting of reviews, original research, and application studies across all sectors, including engineering, optics, bio-medicine, cosmetics, textiles, resource sustainability and science. Applied research into nano-materials, particles, nano-structures and fabrication, diagnostics and analytics, drug delivery and toxicology constitute the primary direction of the journal.
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