Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?

Q Medicine

Progress in Histochemistry and Cytochemistry Pub Date : 2014-09-01 DOI:10.1016/j.proghi.2014.09.001

Marília I. Figueira , Henrique J. Cardoso , Sara Correia, Cláudio J. Maia, Sílvia Socorro

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引用次数: 19

Abstract

The c-KIT, a tyrosine kinase receptor, and its ligand the stem cell factor (SCF) play an important role in the production of male and female gametes. The interaction of SCF with c-KIT is required for germ cell survival and growth, and abnormalities in the activity of the SCF/c-KIT system have been associated with human infertility. Recently, it was demonstrated that gonadotropic and sex steroid hormones, among others, regulate the expression of SCF and c-KIT in testicular and ovarian cells. Therefore, the hormonal (de)regulation of SCF/c-KIT system in the testis and ovary may be a cause underpinning infertility. In the present review, we will discuss the effects of hormones modulating the expression levels of SCF and c-KIT in the human gonads. In addition, the implications of hormonal regulation of SCF/c-KIT system for germ cell development and fertility will be highlighted.

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c-KIT受体及其配体的激素调节:对人类不孕症的影响?

酪氨酸激酶受体c-KIT及其配体干细胞因子(SCF)在雄性和雌性配子的产生中起着重要作用。SCF与c-KIT的相互作用是生殖细胞存活和生长所必需的，SCF/c-KIT系统活性异常与人类不育有关。最近，研究表明促性腺激素和性类固醇激素等调节睾丸和卵巢细胞中SCF和c-KIT的表达。因此，睾丸和卵巢中SCF/c-KIT系统的激素(de)调节可能是导致不育的原因之一。在这篇综述中，我们将讨论激素对人类性腺中SCF和c-KIT表达水平的调节作用。此外，还将重点介绍SCF/c-KIT系统的激素调控对生殖细胞发育和生育的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Histochemistry and Cytochemistry 生物-细胞生物学

CiteScore

4.67

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Progress in Histochemistry and Cytochemistry publishes comprehensive and analytical reviews within the entire field of histochemistry and cytochemistry. Methodological contributions as well as papers in the fields of applied histo- and cytochemistry (e.g. cell biology, pathology, clinical disciplines) will be accepted.